Oxidative Medicine and Cellular Longevity

Review Article

NADPH Oxidase 1 and Its Derived Reactive Oxygen Species Mediated Tissue Injury and Repair

Table 1

Nox1 expression, intracellular signaling, and function.


Cells involved	Intracellular signaling	Function	References

Intestinal epithelial cell; colon carcinoma cells (Caco2 and HT29)	IL13-Nox1-ERK/STAT6-TFF3/Bcl-xl; Nox1-RhoA-alpha3 integrin	Proliferation and differentiation; migration	[29, 36, 37, 40]
HaCaT; GM16	Ca²⁺-Nox1-PGE₂; Ca²⁺/serum-Nox1-vimentin/K8/K18	Proliferation and host defense; skin injury; apoptosis; migration	[17, 19, 22, 30, 31, 34, 38]
Lung epithelial cell	Nox1-JNK/ERK/Caspase-3	Cell death and protection	[18, 41]
Corneal stromal fibroblast		May participate in inflammation	[42]
Mouse embryonic fibroblast		Ischemia-reperfusion injury	[43]
NIH 3T3 fibroblast; rat kidney fibroblast	Ras-Nox1-Rho-actin stress fibers and focal adhesions	Tumorigenic conversion	[15, 35]
Fibrosarcoma L929 cells	TNF-TRADD/RIP1/Rac1/Nox1	Necrosis	[44]
Human BJ foreskin fibroblast and IMR-90 lung fibroblast	CCN1-Nox1/Rac-ERK/p38 MAPK-p16^INK4a/pRb	Senescence and expression of antifibrotic genes	[52]
Mouse vessel	Angiotensin II-Nox1-nitric oxide	Hypertension	[59]
Mouse aorta	Angiotensin II-Nox1-tissue inhibitor of metalloproteinase 1	Aortic dissection	[60]
Human aortic endothelial cell	Hyperglycemia-Nox1-proinflammatory and profibrotic markers	Atherosclerosis	[61]
Rat kidney cell; tumor cells and vessel; sinusoidal endothelial cell	K-Ras-Nox1-ERK-sp1-VEGF; Nox1-VEGF/VEGFR/MMP	Upregulate VEFG expression; increase tumorigenicity and upregulate VEGF/VEGFR and MMP; tubulogenic	[64, 65, 67]
Vascular smooth muscle cell	uPA-Nox1/Nox4; PDGF-Nox1-cofilin	Migration; proliferation and necrosis	[68–70]