Research Article

[Retracted] Antiaging Properties of a Grape-Derived Antioxidant Are Regulated by Mitochondrial Balance of Fusion and Fission Leading to Mitophagy Triggered by a Signaling Network of Sirt1-Sirt3-Foxo3-PINK1-PARKIN

Figure 2

Immunofluorescence multichromatic projections of mitochondrial Sirt3 and the nuclear factor Foxo3a in the ischaemic (IR) cardiac specimens after treatments with resveratrol or longevinex. Panels (a1–a4) are administration of vehicle only; panels (b1–b4) are administration of resveratrol; panels (c1–c4) are administration of longevinex, where (1) is counterstaining of nuclei with Hoechst 33342 (blue), (2) is the immunofluorescence images of Sirt3 (green), (3) is the immunofluorescence images of Foxo3a (red), and (4) is overlay of (1–3) images. Nuclear localization of Foxo3a is indicated with white arrows. The confocal images were taken with optical Z-step of 0.5 µm.
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