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Oxidative Medicine and Cellular Longevity
Volume 2014 (2014), Article ID 381413, 12 pages
Research Article

The Potential Protective Effect of Physalis peruviana L. against Carbon Tetrachloride-Induced Hepatotoxicity in Rats Is Mediated by Suppression of Oxidative Stress and Downregulation of MMP-9 Expression

1Zoology Department, Faculty of Science, King Saud University, Riyadh 11451, Saudi Arabia
2Zoology and Entomology Department, Faculty of Science, Helwan University, Cairo 11795, Egypt
3Biological Science Department, Faculty of Dentistry, Modern Sciences and Arts (MSA) University, Giza 12111, Egypt
4Biochemistry and Molecular Biology Department, Faculty of Biotechnology, Modern Sciences and Arts (MSA) University, Giza 12111, Egypt
5Experimental Biology Department, Faculty of Science, Masaryk University, 62500 Brno, Czech Republic
6Biochemistry and Molecular Biology Department, Asturias Institute of Biotechnology, University of Oviedo, 33006 Oviedo, Spain

Received 29 November 2013; Revised 3 February 2014; Accepted 6 February 2014; Published 27 April 2014

Academic Editor: Vladimir Jakovljevic

Copyright © 2014 Ebtisam M. Al-Olayan et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Supplementary Material

GC-MS chromatogram of the physalis showed 29 peaks indicating the presence of 29 phytochemical constituents. On comparison of the mass spectra of the constituents with Wiley9 combined with NIST 11 libraries, the 29 phytoconstituents were characterized and identified as it shown in Table S1. The identified phytochemical constituent’s mass spectra are Oleic acid, eicosyl ester (5.04%), Colchifoleine (1.48 %), 3β,11β,21-Trihydroxy-20-oxo-5α-pregnan-18-oic acid 18,11-lactone (0.63%), 1-Hydroxy-2-(2,3,4,6-tetra-O-acetyl-beta-D-glucopyranosyl)-9H-xanthene-3,6,7-triyl triacetate (0.81%), kaempferol 3-O-rutinoside (1.40%), 25β-Cholan-24-oic acid, 3,12-dioxo- (2.58%), alpha-D-Glucopyranoside, methyl 2-(acetylamino)-2-deoxy-3-O-(trimethylsilyl)-, cyclic methylboronate (1.62%), ethyl iso-allocholate (1.99%), Quercetin 3,4',7-trimethyl ether (3.11%), Folic Acid (0.95%), 1,25-Dihydroxyvitamin D2 (1.27%), Docosane (0.93), 3-Hydroxy-4,4-dimethyl-7-oxoandrost-5-en-17-yl acetate (0.71%), (5β)Pregnane-3,20β-diol, 14α,18α-[4-methyl-3-oxo-(1-oxa-4-azabutane-1,4-diyl)], diacetate (1.45%), Pregna-4,6-diene-21-carboxylic acid, 17-hydroxy-3-oxo-, γ-lactone (0.75%), Hexadecatrienoic acid, methyl ester (0.64%), beta-k-strophanthin (2.48%), 2,2,4,9,11,11-Hexamethyl dodecane (0.66%), Cholest-5-en-3-one (0.63%), 9,12,15-Octadecatrienoic acid (2-phenyl-1,3-dioxolan-4-yl)methyl ester (0.89%), 9-cis-Hexadecenoic acid (0.93%), 3,7,11-Trihydroxypregnan-20-one (0.99%), Ceanothine C (1.26%), Methyl-9,9,10,10-D4-octadecanoate (4.01%), Lucenin-2 (1.50%), Betulin (0.62%), (5á)Pregnane-3,20á-diol (0.97%), Anodendroside G, monoacetate (0.64%) and 7,8-Epoxylanostan-11-ol, 3-acetoxy- (0.61%).

  1. Supplementary Table