Research Article

The Effects of Sesquiterpenes-Rich Extract of Alpinia oxyphylla Miq. on Amyloid-β-Induced Cognitive Impairment and Neuronal Abnormalities in the Cortex and Hippocampus of Mice

Table 1

Retention times, MS, and MS/MS2 fragmentation patterns of the substances in chloroform extract of Alpinia oxyphylla.

Peak (min)MS+ (/)Major fragments (positive ion mode) (/)Tentative identification

11.08192.1234 175.1M+H-H2O+ 151.1M+H-CH2CO+
133.1M+H-CH2CO-H2O+
Oxyphyllanene A

21.22153.8901110.8M+H-CO2+Protocatechuic acid

33.47220.1544 177.1 133.1Unknown

43.96252.1821 235.1M+H-H2O+ 206.1M-3CH3+
189.1M+H-3CH3-H2O+ 177.1 
M-C3H5-2OH+ 107.1
11S-nootkatone-11,12-diol

54.06252.1797 235.1M+H-H2O+ 206.1M-3CH3+
189.1M+H-3CH3-H2O+ 177.1 
M-C3H5-2OH+ 107.1
11R-nootkatone-11,12-diol

66.62194.1307177.1M+H-H2O+ 149.1M+H-H2O-CO+ 135.1 
M+H-H2O-CO-CH3+ 120.1M+H-H2O-CO-2CH3+
Teuhetenone A

78.10194.1389 177.1M+H-H2O+ 161.1M+H-H2O-CH2+
137.1M+H-H2O-CO-CH2+
Teuhetenone B

810.18220.1547 203.1 → 159.1Unknown

914.21222.1705 180.1 → 138.1Unknown

1015.82216.1595 179.1 → 137.1Unknown

1116.48234.1704 217.2M+H-H2O+ 207.2M+H-CO+ 203.2M+H-H2O-CH2+
→ 189.2M+H-H2O-2CH2+
Oxyphyllol B

1220.47218.1671176.1M+H-C3H6+ → 163.1M+H-C3H5-CH+ → 
149.1M+H-C3H5-CH-CH2+ → 135.1M+H-C3H5-CH-CO+
Nootkatone

1324.53Dibutyl phthalate