The Attenuation of Moutan Cortex on Oxidative Stress for Renal Injury in AGEs-Induced Mesangial Cell Dysfunction and Streptozotocin-Induced Diabetic Nephropathy Rats

Figure 3

Effect of MC on the body weight loss (a), blood glucose level (b), serum creatinine content (c), and urine protein content (d) in STZ-induced DN rats and kidney weight (e). After being treated with high-glucose-fat diet, following with a single intraperitoneal injection of STZ (30 mg kg⁻¹), the rats were treated with MC of high dose (5 g kg⁻¹), medium dose (2.5 g kg⁻¹), low dose (1.25 g kg⁻¹), and positive drugs (AG and VE, 0.1 g kg⁻¹, resp.) for 30 days. ^&&&𝑃<0.001, model versus blank control; ^𝜏𝜏𝜏𝑃<0.001, AG versus model; ^∗∗∗𝑃<0.001, VE versus model; ^###𝑃<0.001, ^##𝑃<0.01, ^#𝑃<0.05, high-dose versus model, medium-dose versus model. Data from individual experiments are presented as means ± SD (𝑛=6).

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