Dietary Blueberry and Bifidobacteria Attenuate Nonalcoholic Fatty Liver Disease in Rats by Affecting SIRT1-Mediated Signaling Pathway

Figure 5

Immunohistochemistry (IHC) analysis for the effect of blueberry juice and bifidobacteria on SREBP-1c expression in NAFLD rat livers (200x). CG: in control group, SREBP-1c was lowly expressed with light brown color. MG: in NAFLD model group, SREBP-1c was highly expressed with dark brown color. SI: in NAFLD model group with SIRT1 RNAi, SREBP-1c was highly expressed with dark brown color. BJ: in blueberry juice group, SREBP-1c was lowly expressed with light brown color. BJSI: in blueberry juice and SIRT1 RNAi group, the expression of SREBP-1c was significantly enhanced with dark brown color. BJB: in blueberry juice and bifidobacteria group, SREBP-1c was lowly expressed with light brown color. BJBSI: in blueberry juice and bifidobacteria and SIRT1 RNAi group, the expression of SREBP-1c was significantly enhanced with dark brown color.