Hemin Attenuates Cisplatin-Induced Acute Renal Injury in Male Rats

Table 1

The results of biochemical analysis in control and experimental groups^a.

Parameters	Unit	Control	CP	CP + hemin	Hemin
Urea	mg/dL	48.60 ± 1.50	151.61 ± 10.02^b	86.61 ± 3.02^b,c	53.60 ± 3.20^c
Creatinine	mg/dL	0.81 ± 0.11	5.14 ± 0.76^b	1.45 ± 0.69^c	0.78 ± 0.08^c
TBARS	nmole MDA/g tissue	6.44 ± 1.67	11.00 ± 1.05^b	7.26 ± 2.74	4.06 ± 1.53^c
NO	mole/g tissue	16.42 ± 0.98	19.58 ± 1.50^b	13.16 ± 0.71^b,c	11.86 ± 0.84^b,c
NOS	nmole/g tissue	5.56 ± 0.84	25.61 ± 7.50^b	16.34 ± 2.19	6.07 ± 0.89^c
GPx	mU/mg protein	353.51 ± 44.43	238.49 ± 40.83^b	311.15 ± 25.76	376.81 ± 30.18^c
SOD	U/mg protein	18.14 ± 2.76	14.01 ± 1.85	17.59 ± 1.83	18.08 ± 1.15
GR	mU/mg protein	98.79 ± 8.40	67.63 ± 6.03^b	86.26 ± 9.13	105.75 ± 10.73^c
GSH	mole/mg protein	6.68 ± 1.10	6.93 ± 0.59	9.15 ± 1.01^b	10.05 ± 0.37^b,c

TBARS: thiobarbituric acid reactive substances, MDA: malondialdehyde, NO: nitric oxide, NOS: nitric oxide synthetase, GPx: glutathione peroxidase, SOD: superoxide dismutase, GR: Glutathione reductase, and GSH: reduced glutathione.
^aResults are expressed as mean ± SE for six replicates.
^bSignificantly different from control at < 0.05 by one-way ANOVA.
^cSignificantly different from CP at < 0.05 by one-way ANOVA.