Lipoxygenase Pathway Mediates Increases of Airway Resistance and Lung Inflation Induced by Exposure to Nanotitanium Dioxide in Rats

Figure 4

Aerosolized nanoparticles of titanium dioxide (4 mg/kg) induced significant increases of functional residual capacity (FRC) and lung compliance (Cchord) and the effects of leukotriene receptor antagonist (MK571) and leukotriene synthase inhibitor (MK886) before-treatment. (***𝑃<0.001; ⁺𝑃<0.05; ⁺⁺𝑃<0.01; ⁺⁺⁺𝑃<0.001. * denotes comparison before- and after-exposure; + denotes comparison with nanoexposure control.)

(a)

(b)