Lipoxygenase Pathway Mediates Increases of Airway Resistance and Lung Inflation Induced by Exposure to Nanotitanium Dioxide in Rats

Figure 6

Aerosolized nanoparticles of titanium dioxide (4 mg/kg) induced significant increases in white blood cell count (WBC) and lactic dehydrogenase (LDH) and the effects of leukotriene receptor antagonist (MK571) and leukotriene synthase inhibitor (MK886) before-treatment. (**𝑃<0.01; ***𝑃<0.001; ⁺𝑃<0.05; ⁺⁺𝑃<0.01. * denotes comparison before- and after-exposure; + denotes comparison with nanoexposure control.)

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