Multimarker Screening of Oxidative Stress in Aging

Table 2

Potential pathogenic role of 8-isoprostane in several diseases (reviewed in [46]).

Disease	Potential pathogenic role of 8-isoprostane
Atherosclerosis	(i) Vasoconstriction in blood vessels; (ii) Influencing the aggregation of platelets; (iii) Inducement of proliferation of smooth muscle cells; (iv) Stimulation of proliferation of calcification blood vessel cells; (v) Inhibition of differentiation of preosteoblasts
Diabetes mellitus	(i) Increase in DNA synthesis in smooth muscle cells; (ii) Inducement of proliferation of smooth muscle cells; (iii) Influencing membrane fluidity and permeability; (iv) Renal vasoconstriction can cause systemic hypertension
Hepatorenal syndrome	(i) Renal vasoconstriction; (ii) Increasing the release of endothelin-1
Preeclampsia	Renal vasoconstriction
Lung diseases	(i) Bronchoconstriction; (ii) Vasoconstriction of lung artery