Oxidative Medicine and Cellular Longevity / 2014 / Article / Fig 2

Review Article

A Review on Hemeoxygenase-2: Focus on Cellular Protection and Oxygen Response

Figure 2

Catalytic reaction of HOs and BVR. The sequence is shown in three stages, separated by three well-defined intermediates: ferric-hydroperoxide, α-meso-hydroxyheme, and α-verdoheme. The final products of the reaction are CO, biliverdin IXα, and Fe2+. Biliverdin IXα is then reduced by BVR.

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