A Review on Hemeoxygenase-2: Focus on Cellular Protection and Oxygen Response
Structure of the Hmox2 and multiple transcripts of rat HO-2. Introns are denoted by thin lines, coding sequences by black boxes. In the promoter sequence, the TATA-like sequence is observed. The upstream regulatory sequence GRE is shown. Nested sequence HMG-17 cDNA is indicated by a green line. Two potential polyadenylation signals are located in the 3′UTR in a purple arrow. The start codon is denoted as +1. Three different transcripts are identified as result of sequence variability in the upstream region from nucleotide −37. Figure based on information reported by [63–65].
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