Effect of the Antihypertensive Drug Enalapril on Oxidative Stress Markers and Antioxidant Enzymes in Kidney of Spontaneously Hypertensive Rat
Table 1
Effect of enalapril treatment on urinary protein, creatinine clearance, kidney TAS, TBARS, SOD, and CAT levels in treated and untreated WKY and WKY administered L-NAME rats.
Parameters
Groups
Age
WKY
WKY+E
WKY+LN
WKY+E+LN
TAS (umol/mg protein)
4 weeks
2.52 ± 0.03
—
—
—
16 weeks
3.21 ± 0.06
3.34 ± 0.06
—
—
28 weeks
3.47 ± 0.04
3.48 ± 0.05
2.67 ± 0.12
3.68 ± 0.06
TBARS (umol/mg protein)
4 weeks
1.87 ± 0.05
—
—
—
16 weeks
1.96 ± 0.11
1.94 ± 0.16
—
—
28 weeks
2.28 ± 0.11
2.23 ± 0.13
3.05 ± 0.12
2.15 ± 0.06
SOD (U/mg protein)
4 weeks
82.50 ± 5.8
—
—
—
16 weeks
78.50 ± 3.94
82.33 ± 2.53
—
—
28 weeks
79.50 ± 3.10
78.83 ± 2.20
61.33 ± 1.17
74.83 ± 0.95
CAT (U/mg protein)
4 weeks
857 ± 21
—
—
—
16 weeks
781 ± 14
706 ± 7
—
—
28 weeks
768 ± 12
698 ± 15
725 ± 22
699 ± 16
Urinary protein (mg/day)
4 weeks
0.98 ± 0.22
—
—
—
16 weeks
5.16 ± 0.41
6.08 ± 0.42
—
—
28 weeks
5.28 ± 0.34
5.95 ± 0.43
9.19 ± 0.39
5.80 ± 0.30
Creatinine clearance (mL/min)
4 weeks
0.59 ± 0.05
—
—
—
16 weeks
1.69± 0.06
1.67 ± 0.07
—
—
28 weeks
1.79± 0.08
1.77 ± 0.08
1.47 ± 0.03
1.76 ± 0.07
Values are expressed as mean ± SEM ( per group). WKY: WKY with no treatment, WKY+E : WKY+enalapril, WKY+LN : WKY+L-NAME, and WKY+E+LN : WKY+enalapril+L-NAME. and WKY+LN compared to WKY, WKY+E, and WKY+E+LN.
