The Effects of Quinacrine, Proglumide, and Pentoxifylline on Seizure Activity, Cognitive Deficit, and Oxidative Stress in Rat Lithium-Pilocarpine Model of Status Epilepticus

Figure 1

Performance in water-maze of animals that experienced SE along with their controls as well as the SE groups that were pretreated with Ptx, Qcn, and Pgm. Mean latency to reach the hidden platform in seconds SEM (-axis) on each testing day (-axis) shows that animals subjected to SE were slower in finding the platform (cognitive effect) than the controls on all four testing days. Treatment with Ptx, Qcn, and Pgm in varying doses was effective in improving the cognitive function in the order Ptx < Pgm < Qcn and dose-dependently. Li = lithium chloride; Pilo = pilocarpine; SE = status epilepticus; doses of drugs in mg/kg body weight: Ptx-1, Ptx-2, and Ptx-3 = 20, 40, and 60; Pgm-1, Pgm2, and Pgm3 = 250, 500, and 750; and Qcn-1, Qcn-2, and Qcn-3 = 5, 15, and 30, respectively. # represents significance as compared to control (), whereas , and show , , and , respectively, as compared to SE group by one-way ANOVA.

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