Leucocyte Telomere Shortening in relation to Newly Diagnosed Type 2 Diabetic Patients with Depression

Table 2

Demographic, clinical, and biochemical parameters of the study subjects of subgroups with/without depression in T2D^a and Ctrl^b groups.

	T2D		Ctrl		𝐹	𝑃
	D+	D−	D+	D−
	𝑛=17	𝑛=54	𝑛=6	𝑛=46
Age (yrs)	54.71±8.10	54.83±8.58	55.33±6.56	51.22±8.32	1.823	0.147
Male [(𝑛(%)]	10 (58.82)	24 (44.44)	3 (50.00)	19 (41.30)	—	0.656
Current smokers [(𝑛(%)]	5 (29.41)	16 (29.63)	2 (33.33)	12 (26.09)	—	0.971
Current drinkers [(𝑛(%)]	2 (11.76)	11 (20.37)	1 (16.67)	7 (15.22)	—	0.834
Use of aspirin [(𝑛(%)]	1 (5.88)	7 (12.96)	0 (0.00)	4 (8.70)	—	0.653
Use of statin [(𝑛(%)]	3 (17.65)	4 (7.41)	1 (16.67)	3 (6.52)	—	0.474
Use of antihypertensive drugs [(𝑛(%)]	3 (17.64)^#	3 (5.56)^#	0 (0.00)	5 (10.87)	—	0.00
HADS-D (point)	12 (10, 12)^*⊙	7 (6, 8)^#	12 (10, 12)*	7 (6, 8)	—	0.000
BMI (kg/m^2)	24.96±1.93^∗	25.29±2.28^∗	24.00±2.32^∗	23.84±1.36	5.033	0.003
Waist circumstance (cm)	87 (80, 91)*	88 (82, 94)*	81 (77, 87)	82 (78, 86)	—	0.000
WHR	0.82; (0.74, 0.88)	0.85; (0.79, 0.90)*	0.82; (0.75, 0.86)	0.80; (0.74, 0.84)	—	0.006
Systolic blood pressure (mmHg)	134 (120, 141)	131 (120, 141)	128 (123, 130)	126 (123, 130)	—	0.171
Diastolic blood pressure (mmHg)	79 (70, 84)	82 (75, 89)*	78 (72, 85)	74 (68, 131)	—	0.004
HbA1c (%)	8.4 (8, 9.1)^*#	8.2 (7.5, 8.7)^*#	5.3 (5.2, 5.5)	5.1 (4.7, 5.4)	—	0.000
FPG (mmol/L)	9.42±1.66^∗#	8.50±1.23^∗#	5.42±0.28	5.44±0.36	101.427	0.000
FIN (mIU/L)	12.55; (6.69, 15.02)	11.09; (6.99, 13.19)	12.95; (9.57, 16.40)	12.00; (7.74, 13.23)	—	0.617
HOMA-IR	5.54; (3.24, 6.25)*	4.19; (2.58, 5.02)*	3.09; (2.26, 3.70)	2.91; (2.00, 3.23)	—	0.000
Total cholesterol (mmol/L)	4.57±1.03^∗#	4.73±0.87^∗#	4.03±0.26	4.06±0.57	6.821	0.000
Triglyceride (mmol/L); HDL-cholesterol (mmol/L)	1.89; (1.34, 1.88)*	1.91; (1.08, 2.36)*	1.74; (1.18, 2.13)	1.23; (0.85, 1.55)	—	0.001
	1.15±0.26	1.14±0.23	1.20±0.40	1.26±0.25	1.841	0.143
LDL-cholesterol (mmol/L)	2.39±0.92	2.50±0.74	2.10±0.81	2.22±0.66	1.458	0.229
8-OHdG (ng/mL)	1.80±0.42^∗	1.48±0.44^∗	1.53±0.26	1.09±0.34	15.722	0.000
T/S ratio	1.70; (1.36, 2.06)^*⊙	2.11; (1.82, 2.42)*	2.01; (1.91, 2.13)*	2.32; (2.14, 2.47)	—	0.000

Data are means ± SD, 𝑛 (%), or median (interquartile range).
T2D: type 2 diabetic group, Ctrl: control group, HADS-D: Depression Subscale of Hospital Anxiety and Depression Scale, BMI: body mass index, WHR: waist-to-hip ratio, FPG: fasting plasma glucose, FIN: fasting insulin, HOMA-IR: homeostasis model assessment-insulin resistance [HOMA - IR = FIN (mIU/L) × FPG (mmol/L)/22.5], 8-OHdG: Human 8-Hydroxy-desoxyguanosine.
^asubgroup with/without depression in T2D is shown as T2D(D+)/T2D(D−), respectively,
^bsubgroup with/without depression in Ctrl group is shown as Ctrl(D+)/Ctrl(D−), respectively.
^∗𝑃<0.05 for T2D(D+)/T2D(D−)/Ctrl(D+) versus Ctrl(D−).
^#𝑃<0.05 for T2D(D+)/T2D(D−) versus Ctrl(D+).
^⊙𝑃<0.05 for T2D(D+) versus T2D(D−).