Astragalus Polysaccharide Suppresses Doxorubicin-Induced Cardiotoxicity by Regulating the PI3k/Akt and p38MAPK Pathways

Figure 4

APS ameliorates doxorubicin-induced cardiotoxicity and apoptosis in vivo. (a) H&E staining of normal mice (Con) and mice with doxorubicin-induced heart failure (HF) (). (b) Representative TUNEL staining of apoptotic cells in normal and doxorubicin-induced heart injury samples. Red staining indicates TUNEL-positive cells (, , ). (c) Western blotting and average data for caspase 3, caspase 9, and Bcl2 in sham, doxorubicin-induced heart injury mice (DOX), and mice with APS pretreatment followed by doxorubicin treatment (APS + DOX) (, , ). (d) Mouse heart function 5 days after doxorubicin injection as shown by fractional shortening % (FS %) and ejection fraction % (EF %) (, , ).

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