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Oxidative Medicine and Cellular Longevity
Volume 2014, Article ID 693680, 6 pages
http://dx.doi.org/10.1155/2014/693680
Research Article

Positive Relationship between Total Antioxidant Status and Chemokines Observed in Adults

1Department of Epidemiology and Environmental Health, School of Public Health and Health Professions, State University of New York at Buffalo, Buffalo, NY 14214, USA
2Department of Biotechnical and Clinical Laboratory Sciences, State University of New York at Buffalo, Buffalo, NY 14214, USA
3Department of Environmental Health, Peking University Health Science Center, Beijing 100191, China
4Department of Biostatistics, State University of New York at Buffalo, Buffalo, NY 14214, USA

Received 10 June 2014; Revised 10 August 2014; Accepted 11 August 2014; Published 28 August 2014

Academic Editor: Mahesh Thirunavukkarasu

Copyright © 2014 Yanli Li et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Objective. Human evidence is limited regarding the interaction between oxidative stress biomarkers and chemokines, especially in a population of adults without overt clinical disease. The current study aims to examine the possible relationships of antioxidant and lipid peroxidation markers with several chemokines in adults. Methods. We assessed cross-sectional associations of total antioxidant status (TAS) and two lipid peroxidation markers malondialdehyde (MDA) and thiobarbituric acid reactive substances (TBARS) with a suite of serum chemokines, including CXCL-1 (GRO-), CXCL-8 (IL-8), CXCL-10 (IP-10), CCL-2 (MCP-1), CCL-5 (RANTES), CCL-8 (MCP-2), CCL-11 (Eotaxin-1), and CCL-17 (TARC), among 104 Chinese adults without serious preexisting clinical conditions in Beijing before 2008 Olympics. Results. TAS showed significantly positive correlations with MCP-1 (, ), MCP-2 (, ), Eotaxin-1 (, ), and TARC (, ). The positive correlations remained unchanged after controlling for age, sex, body mass index, smoking, and alcohol drinking status. No associations were found between any of the chemokines measured in this study and MDA or TBARS. Similar patterns were observed when the analyses were limited to nonsmokers. Conclusion. Total antioxidant status is positively associated with several chemokines in this adult population.