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Oxidative Medicine and Cellular Longevity
Volume 2014, Article ID 720347, 9 pages
http://dx.doi.org/10.1155/2014/720347
Research Article

Oxidative Stress Is Predominant in Female but Not in Male Patients with Autoimmune Thrombocytopenia

Institute for Transfusion Medicine, Charité University Medicine, Augustenburger Platz 1, 13353 Berlin, Germany

Received 23 September 2013; Accepted 10 December 2013; Published 6 January 2014

Academic Editor: Swaran J. S. Flora

Copyright © 2014 Julian Kamhieh-Milz and Abdulgabar Salama. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. J. N. George, S. H. Woolf, G. E. Raskob et al., “Idiopathic thrombocytopenic purpura: a practice guideline developed by explicit methods for the American Society of Hematology,” Blood, vol. 88, no. 1, pp. 3–40, 1996. View at Google Scholar · View at Scopus
  2. F. Rodeghiero, R. Stasi, T. Gernsheimer et al., “Standardization of terminology, definitions and outcome criteria in immune thrombocytopenic purpura of adults and children: report from an international working group,” Blood, vol. 113, no. 11, pp. 2386–2393, 2009. View at Publisher · View at Google Scholar · View at Scopus
  3. M. D. Coopamah, M. B. Garvey, J. Freedman, and J. W. Semple, “Cellular immune mechanisms in autoimmune thrombocytopenic purpura: an update,” Transfusion Medicine Reviews, vol. 17, no. 1, pp. 69–80, 2003. View at Publisher · View at Google Scholar · View at Scopus
  4. D. B. Cines, J. B. Bussel, H. A. Liebman, and E. T. Luning Prak, “The ITP syndrome: pathogenic and clinical diversity,” Blood, vol. 113, no. 26, pp. 6511–6521, 2009. View at Publisher · View at Google Scholar · View at Scopus
  5. R. Stasi, M. L. Evangelista, E. Stipa, F. Buccisano, A. Venditti, and S. Amadori, “Idiopathic thrombocytopenic purpura: current concepts in pathophysiology and management,” Thrombosis and Haemostasis, vol. 99, no. 1, pp. 4–13, 2008. View at Publisher · View at Google Scholar · View at Scopus
  6. A. Salama, “Current treatment options for primary immune thrombocytopenia,” Expert Review of Hematology, vol. 4, no. 1, pp. 107–118, 2011. View at Publisher · View at Google Scholar · View at Scopus
  7. R. McMillan, “Autoantibodies and autoantigens in chronic immune thrombocytopenic purpura,” Seminars in Hematology, vol. 37, no. 3, pp. 239–248, 2000. View at Google Scholar · View at Scopus
  8. M. Kuwana and Y. Ikeda, “The role of autoreactive T-cells in the pathogenesis of idiopathic thrombocytopenic purpura,” International Journal of Hematology, vol. 81, no. 2, pp. 106–112, 2005. View at Publisher · View at Google Scholar · View at Scopus
  9. G. Bartosz, “Peroxynitrite: mediator of the toxic action of nitric oxide,” Acta Biochimica Polonica, vol. 43, no. 4, pp. 645–659, 1996. View at Google Scholar · View at Scopus
  10. H. Ischiropoulos, “Biological selectivity and functional aspects of protein tyrosine nitration,” Biochemical and Biophysical Research Communications, vol. 305, no. 3, pp. 776–783, 2003. View at Publisher · View at Google Scholar · View at Scopus
  11. H. Ischiropoulos and A. Gow, “Pathophysiological functions of nitric oxide-mediated protein modifications,” Toxicology, vol. 208, no. 2, pp. 299–303, 2005. View at Publisher · View at Google Scholar · View at Scopus
  12. R. P. Patel, J. McAndrew, H. Sellak et al., “Biological aspects of reactive nitrogen species,” Biochimica et Biophysica Acta, vol. 1411, no. 2-3, pp. 385–400, 1999. View at Publisher · View at Google Scholar · View at Scopus
  13. S. Kannan, “Free radical theory of autoimmunity,” Theoretical Biology and Medical Modelling, vol. 3, article 22, 2006. View at Google Scholar
  14. B. T. Kurien, K. Hensley, M. Bachmann, and R. H. Scofield, “Oxidatively modified autoantigens in autoimmune diseases,” Free Radical Biology and Medicine, vol. 41, no. 4, pp. 549–556, 2006. View at Publisher · View at Google Scholar · View at Scopus
  15. B. T. Kurien and R. H. Scofield, “Autoimmunity and oxidatively modified autoantigens,” Autoimmunity Reviews, vol. 7, no. 7, pp. 567–573, 2008. View at Publisher · View at Google Scholar · View at Scopus
  16. M.-Y. Chou, L. Fogelstrand, K. Hartvigsen et al., “Oxidation-specific epitopes are dominant targets of innate natural antibodies in mice and humans,” Journal of Clinical Investigation, vol. 119, no. 5, pp. 1335–1349, 2009. View at Publisher · View at Google Scholar · View at Scopus
  17. Y. Ohno, T. Kanoh, and H. Uchino, “Idiopathic thrombocytopenic purpura with defective oxidative metabolism of neutrophils,” Acta Haematologica Japonica, vol. 47, no. 6, pp. 1257–1264, 1984. View at Google Scholar · View at Scopus
  18. A. G. Brox, K. Howson-Jan, and A. A. Fauser, “Treatment of idiopathic thrombocytopenic purpura with ascorbate,” British Journal of Haematology, vol. 70, no. 3, pp. 341–344, 1988. View at Google Scholar · View at Scopus
  19. S. J. Jubelirer, “Pilot study of ascorbic acid for the treatment of refractory immune thrombocytopenic purpura,” American Journal of Hematology, vol. 43, no. 1, pp. 44–46, 1993. View at Google Scholar · View at Scopus
  20. A. Karduss Urueta, M. R. Morales Polanco, J. Pizzuto Chávez, and L. A. Meillón García, “Results of the treatment of chronic idiopathic thrombocytopenic purpura with ascorbic acid,” Gaceta Medica de Mexico, vol. 129, no. 1, pp. 23–25, 1993. View at Google Scholar · View at Scopus
  21. N. Vianelli, L. Gugliotta, L. Gianni, M. M. Belmonte, L. Catani, and S. Tura, “Ascorbic acid for the treatment of chronic refractory idiopathic thrombocytopenic purpura (ITP),” Haematologica, vol. 77, no. 1, pp. 92–93, 1992. View at Google Scholar · View at Scopus
  22. S. Akbayram, M. Dogan, C. Akgün et al., “The association of oxidant status and antioxidant capacity in children with acute and chronic ITP,” Journal of Pediatric Hematology/Oncology, vol. 32, no. 4, pp. 277–281, 2010. View at Publisher · View at Google Scholar · View at Scopus
  23. B. Zhang, C. Lo, L. Shen et al., “The role of vanin-1 and oxidative stress-related pathways in distinguishing acute and chronic pediatric ITP,” Blood, vol. 117, no. 17, pp. 4569–4579, 2011. View at Publisher · View at Google Scholar · View at Scopus
  24. G. Polat, L. Tamer, K. Tanriverdi, E. Gürkan, F. Baslamisli, and U. Atik, “Levels of malondialdehyde, glutathione and ascorbic acid in idiopathic thrombocytopaenic purpura,” East African Medical Journal, vol. 79, no. 8, pp. 446–449, 2002. View at Google Scholar · View at Scopus
  25. C. Q. Jin, H. X. Dong, P. P. Cheng, J. W. Zhou, B. Y. Zheng, and F. Liu, “Antioxidant status and oxidative stress in patients with chronic ITP,” Scandinavian Journal of Immunology, vol. 77, pp. 482–487, 2013. View at Google Scholar
  26. J. Kamhieh-Milz, G. Bal, V. Sterzer, S. Kamhieh-Milz, O. Arbach, and A. Salama, “Reduced antioxidant capacities in platelets from patients with autoimmune thrombocytopenia purpura (ITP),” Platelets, vol. 23, no. 3, pp. 184–194, 2012. View at Publisher · View at Google Scholar · View at Scopus
  27. C. Neunert, W. Lim, M. Crowther, A. Cohen, L. Solberg Jr., and M. A. Crowther, “The American Society of Hematology 2011 evidence-based practice guideline for immune thrombocytopenia,” Blood, vol. 117, no. 16, pp. 4190–4207, 2011. View at Publisher · View at Google Scholar · View at Scopus
  28. H. Frederiksen and K. Schmidt, “The incidence of idiopathic thrombocytopenic purpura in adults increases with age,” Blood, vol. 94, no. 3, pp. 909–913, 1999. View at Google Scholar · View at Scopus
  29. W. M. Schoonen, G. Kucera, J. Coalson et al., “Epidemiology of immune thrombocytopenic purpura in the General Practice Research Database,” British Journal of Haematology, vol. 145, pp. 235–244, 2009. View at Publisher · View at Google Scholar · View at Scopus
  30. J. B. Segal and N. R. Powe, “Prevalence of immune thrombocytopenia: analyses of administrative data,” Journal of Thrombosis and Haemostasis, vol. 4, no. 11, pp. 2377–2383, 2006. View at Publisher · View at Google Scholar · View at Scopus
  31. C. Vassalle, S. Maffei, C. Boni, and G. C. Zucchelli, “Gender-related differences in oxidative stress levels among elderly patients with coronary artery disease,” Fertility and Sterility, vol. 89, no. 3, pp. 608–613, 2008. View at Publisher · View at Google Scholar · View at Scopus
  32. A. Kikuchi, A. Takeda, H. Onodera et al., “Systemic increase of oxidative nucleic acid damage in Parkinson's disease and multiple system atrophy,” Neurobiology of Disease, vol. 9, no. 2, pp. 244–248, 2002. View at Publisher · View at Google Scholar · View at Scopus
  33. K. Schuessel, S. Leutner, N. J. Cairns, W. E. Müller, and A. Eckert, “Impact of gender on upregulation of antioxidant defence mechanisms in Alzheimer's disease brain,” Journal of Neural Transmission, vol. 111, no. 9, pp. 1167–1182, 2004. View at Publisher · View at Google Scholar · View at Scopus
  34. L. Dreyer, E. Prescott, and F. Gyntelberg, “Association between atherosclerosis and female lung cancer—a Danish cohort study,” Lung Cancer, vol. 42, no. 3, pp. 247–254, 2003. View at Publisher · View at Google Scholar · View at Scopus
  35. E. Ortona, P. Margutti, P. Matarrese, F. Franconi, and W. Malorni, “Redox state, cell death and autoimmune diseases: a gender perspective,” Autoimmunity Reviews, vol. 7, no. 7, pp. 579–584, 2008. View at Publisher · View at Google Scholar · View at Scopus
  36. U. Nussinovitch and Y. Shoenfeld, “The role of gender and organ specific autoimmunity,” Autoimmunity Reviews, vol. 11, no. 6-7, pp. A377–A385, 2012. View at Publisher · View at Google Scholar · View at Scopus
  37. P. Invernizzi, S. Pasini, C. Selmi, M. E. Gershwin, and M. Podda, “Female predominance and X chromosome defects in autoimmune diseases,” Journal of Autoimmunity, vol. 33, no. 1, pp. 12–16, 2009. View at Publisher · View at Google Scholar · View at Scopus
  38. G. Di Comite, M. Grazia Sabbadini, A. Corti, P. Rovere-Querini, and A. A. Manfredi, “Conversation galante: how the immune and the neuroendocrine systems talk to each other,” Autoimmunity Reviews, vol. 7, no. 1, pp. 23–29, 2007. View at Publisher · View at Google Scholar · View at Scopus
  39. A. Lleo, P. M. Battezzati, C. Selmi, M. E. Gershwin, and M. Podda, “Is autoimmunity a matter of sex?” Autoimmunity Reviews, vol. 7, no. 8, pp. 626–630, 2008. View at Publisher · View at Google Scholar · View at Scopus
  40. A. V. Rubtsov, K. Rubtsova, J. W. Kappler, and P. Marrack, “Genetic and hormonal factors in female-biased autoimmunity,” Autoimmunity Reviews, vol. 9, no. 7, pp. 494–498, 2010. View at Publisher · View at Google Scholar · View at Scopus
  41. D. Fairweather and N. R. Rose, “Women and autoimmune diseases,” Emerging Infectious Diseases, vol. 10, no. 11, pp. 2005–2011, 2004. View at Google Scholar · View at Scopus
  42. B. Poljsak, “Strategies for reducing or preventing the generation of oxidative stress,” Oxidative Medicine and Cellular Longevity, vol. 2011, Article ID 194586, 15 pages, 2011. View at Publisher · View at Google Scholar · View at Scopus
  43. J. L. Newton, J. A. Reese, S. I. Watson et al., “Fatigue in adult patients with primary immune thrombocytopenia,” European Journal of Haematology, vol. 86, no. 5, pp. 420–429, 2011. View at Publisher · View at Google Scholar · View at Scopus
  44. S. Tomic, S. Brkic, D. Maric, and A. N. Mikic, “Lipid and protein oxidation in female patients with chronic fatigue syndrome,” Archives of Medical Science, vol. 8, pp. 886–891, 2012. View at Google Scholar
  45. M. Meyer, R. Schreck, and P. A. Baeuerle, “H2O2 and antioxidants have opposite effects on activation of NF-χB and AP-1 in intact cells: AP-1 as secondary antioxidant-responsive factor,” EMBO Journal, vol. 12, no. 5, pp. 2005–2015, 1993. View at Google Scholar · View at Scopus
  46. R. Schreck, P. Rieber, and P. A. Baeuerle, “Reactive oxygen intermediates as apparently widely used messengers in the activation of the NF-κB transcription factor and HIV-1,” EMBO Journal, vol. 10, no. 8, pp. 2247–2258, 1991. View at Google Scholar · View at Scopus
  47. S. J. Kim, P. Angel, R. Lafyatis et al., “Autoinduction of transforming growth factor β1 is mediated by the AP-1 complex,” Molecular and Cellular Biology, vol. 10, no. 4, pp. 1492–1497, 1990. View at Google Scholar · View at Scopus
  48. A. Voigt, A. Rahnefeld, P. M. Kloetzel, and E. Kruger, “Cytokine-induced oxidative stress in cardiac inflammation and heart failure-how the ubiquitin proteasome system targets this vicious cycle,” Frontiers in Physiology, vol. 4, article 42, 2013. View at Google Scholar
  49. B. He, A. Chadburn, E. Jou, E. J. Schattner, D. M. Knowles, and A. Cerutti, “Lymphoma B cells evade apoptosis through the TNF family members BAFF/BLyS and APRIL,” Journal of Immunology, vol. 172, pp. 3268–3279, 2004. View at Google Scholar · View at Scopus
  50. J.-O. Pers, C. Daridon, V. Devauchelle et al., “BAFF overexpression is associated with autoantibody production in autoimmune diseases,” Annals of the New York Academy of Sciences, vol. 1050, pp. 34–39, 2005. View at Publisher · View at Google Scholar · View at Scopus
  51. E.-Y. Moon, J.-H. Lee, S.-Y. Oh et al., “Reactive oxygen species augment B-cell-activating factor expression,” Free Radical Biology and Medicine, vol. 40, no. 12, pp. 2103–2111, 2006. View at Publisher · View at Google Scholar · View at Scopus
  52. F. Tada, M. Abe, K. Kawasaki et al., “B cell activating factor in obesity is regulated by oxidative stress in adipocytes,” Journal of Clinical Biochemistry and Nutrition, vol. 52, pp. 120–127, 2013. View at Google Scholar
  53. F. Emmerich, G. Bal, A. Barakat et al., “High-level serum B-cell activating factor and promoter polymorphisms in patients with idiopathic thrombocytopenic purpura,” British Journal of Haematology, vol. 136, no. 2, pp. 309–314, 2007. View at Publisher · View at Google Scholar · View at Scopus
  54. C. Cerella, S. Coppola, V. Maresca, M. De Nicola, F. Radogna, and L. Ghibelli, “Multiple mechanisms for hydrogen peroxide-induced apoptosis,” Annals of the New York Academy of Sciences, vol. 1171, pp. 559–563, 2009. View at Publisher · View at Google Scholar · View at Scopus
  55. N. Rukoyatkina, U. Walter, and S. Gambaryan, “NO inhibits platelet apoptosis by cGMP-dependent and-independent pathways,” BMC Pharmacology, vol. 9, article P60, 2009. View at Google Scholar
  56. J. Thachil, “Nitric oxide in immune thrombocytopenic purpura,” Hematology, vol. 14, no. 1, pp. 59–62, 2009. View at Publisher · View at Google Scholar · View at Scopus
  57. K. D. Mason, M. R. Carpinelli, J. I. Fletcher et al., “Programmed anuclear cell death delimits platelet life span,” Cell, vol. 128, no. 6, pp. 1173–1186, 2007. View at Publisher · View at Google Scholar · View at Scopus
  58. B. Qi and J. M. Hardwick, “A Bcl-xL timer sets platelet life span,” Cell, vol. 128, no. 6, pp. 1035–1036, 2007. View at Publisher · View at Google Scholar · View at Scopus