Human AP Endonuclease 1: A Potential Marker for the Prediction of Environmental Carcinogenesis Risk

Figure 2

Scheme showing the potential of APE1 as an important modulator in human diseases. APE1 abnormality is known to be associated with the induction of various lethal diseases including cancer. In particular, gene-environment interaction between APE1 malfunction and several environmental factors increases the carcinogenic risk, leading to cancer development. Thus, APE1 can be suggested as one of the potential markers for risk prediction of environmental carcinogenesis.