Research Article

Approach to Reduction of Blood Atherogenicity

Table 4

Effect of whole serum and lipoprotein fractions on total cholesterol content of subendothelial intimal cells cultured from human aorta.

Sera Cholesterol content, % control
SerumLDL VLDLHDL2HDL3

Nonatherogenic,
109 ± 9 106 ± 5113 ± 11 108 ± 15 114 ± 8

Atherogenic,
260 ± 18*292 ± 31*158 ± 13 106 ± 11 121 ± 9

Initial control value of cholesterol was 11.8 ± 0.9  g/105 cells (15 determinations).
The serum and each lipoprotein fraction were added to culture in the concentration of 40% and 250  g protein/mL, respectively. Values listed are mean of 12 determinations ± S.E.M.
*Significant differences from the control.