Bach1 Deficiency and Accompanying Overexpression of Heme Oxygenase-1 Do Not Influence Aging or Tumorigenesis in Mice

Figure 3

Effects of age and Bach1 deficiency on gene expressions in mice. (a) Heat map visualizations of the 530 entities, differentially expressed in the livers of young Bach1-deficient compared with young wild-type mice. Three mice were used for each group. Here and elsewhere the data for heat maps are normalized and represented as median-centered log-transformed values, using average linkage clustering on entities. Red and blue correspond to high and low expression, respectively, compared with the experiment-wide median. (b) Venn diagram shows overlap between the Bach1 knockout gene expression signature in liver and the previously published [39] Bach1 knockout signature in MEF. (c) Heat map visualizations of the 25 entities common for both signatures. Hierarchical clustering on entities and conditions.