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Oxidative Medicine and Cellular Longevity
Volume 2014, Article ID 759293, 12 pages
Review Article

Relevance of the Glutathione System in Temporal Lobe Epilepsy: Evidence in Human and Experimental Models

1Laboratory of Neurochemistry, National Institute of Pediatrics, 04530 Mexico City, Mexico
2Laboratory of Neuroplasticity and Neurodegeneration, CINVESTAV, 07360 Mexico City, Mexico
3Service of Endocrinology, National Institute of Pediatrics, 04530 Mexico City, Mexico
4Laboratory of Pharmacology, National Institute of Pediatrics, 04530 Mexico City, Mexico
5Department of Comparative Biology, Faculty of Sciences, National Autonomous University of Mexico, 04150 Mexico City, Mexico

Received 15 September 2014; Accepted 11 November 2014; Published 30 November 2014

Academic Editor: Elisa Cabiscol

Copyright © 2014 Noemí Cárdenas-Rodríguez et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Oxidative stress, which is a state of imbalance in the production of reactive oxygen species and nitrogen, is induced by a wide variety of factors. This biochemical state is associated with diseases that are systemic as well as diseases that affect the central nervous system. Epilepsy is a chronic neurological disorder, and temporal lobe epilepsy represents an estimated 40% of all epilepsy cases. Currently, evidence from human and experimental models supports the involvement of oxidative stress during seizures and in the epileptogenesis process. Hence, the aim of this review was to provide information that facilitates the processing of this evidence and investigate the therapeutic impact of the biochemical status for this specific pathology.