Mitochondrial Dysfunction: Different Routes to Alzheimer’s Disease Therapy

Figure 1

Nonamyloidgenic or amyloidgenic pathways are originated by different APP processing: the combined cleavage of α- and γ-secretase produces the sAPPα and CTF-α fragments preventing Aβ generation; in contrast, β-secretase cleaves in a different site of APP thus originating, together with -secretase complex, the sAPPβ and Aβ fragments and the intracellular AICD fragment. Aβ through a misfolding step forms fibrillar aggregates.