Promoter Hypermethylation and Suppression of Glutathione Peroxidase 3 Are Associated with Inflammatory Breast Carcinogenesis

Table 2

Scoring of GPX3 expression in normal, non-IBC, and IBC breast tissues.

Score	Normal (𝑛=6)	Non-IBC (𝑛=16)^a	IBC (𝑛=16)^b,c
	𝑛 (%)	𝑛 (≈%)	𝑛 (≈%)
Negative	0 (0%)	5 (31.2%)	11 (68.7%)
+	0 (0%)	7 (43.8%)	3 (18.7%)
++	3 (50%)	4 (25%)	2 (12.5%)
+++	3 (50%)	0	0

Significant 𝑃 value calculated by the Chi-square test.
^aSignificant 𝑃 value (𝑃=0.001) when normal tissues were compared to non-IBC tissues.
^bSignificant 𝑃 value (𝑃<0.001) when normal tissues were compared to IBC tissues.
^cSignificant 𝑃 value (𝑃=0.043) when non-IBC tissues were compared to IBC tissues.
𝑛 = number of patients.