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Oxidative Medicine and Cellular Longevity
Volume 2014 (2014), Article ID 798957, 6 pages
http://dx.doi.org/10.1155/2014/798957
Clinical Study

Ubiquinol Improves Symptoms in Children with Autism

1Pharmacobiochemical Laboratory of 3rd Medical Department, Medical Faculty, Comenius University in Bratislava, Sasinkova 4, 811 08 Bratislava, Slovakia
2Institute of Physiology, Medical Faculty, Comenius University in Bratislava, Sasinkova 4, 811 08 Bratislava, Slovakia
3Department of Biological Science, Purdue University, W. Lafayette, IN 47901, USA

Received 22 May 2013; Revised 16 January 2014; Accepted 16 January 2014; Published 23 February 2014

Academic Editor: Swaran J. S. Flora

Copyright © 2014 Anna Gvozdjáková et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. D. A. Rossignol and R. E. Frye, “Mitochondrial dysfunction in autism spectrum disorders: a systematic review and meta-analysis,” Molecular Psychiatry, vol. 17, no. 3, pp. 290–314, 2012. View at Publisher · View at Google Scholar · View at Scopus
  2. B. Kumar, A. Prakash, R. K. Sewal, B. Medhi, and M. Modi, “Drug therapy in autism: a present and future perspective,” Pharmacological Reports, vol. 64, pp. 1291–1304, 2012. View at Google Scholar
  3. C. Giulivi, Y.-F. Zhang, A. Omanska-Klusek et al., “Mitochondrial dysfunction in autism,” Journal of the American Medical Association, vol. 304, no. 21, pp. 2389–2396, 2010. View at Publisher · View at Google Scholar · View at Scopus
  4. A. Ghanizadeh, M. Berk, H. Farrashbandi, A. A. Shoushtari, and K. A. Villagonzalo, “Targeting the mitochondrial electron transport chain in autism, a systematic review and synthesis of a novel therapeutic approach,” Mitochondrion, vol. 13, no. 5, pp. 515–519, 2012. View at Publisher · View at Google Scholar
  5. E. Napoli, S. Wong, and C. Giulivi, “Evidence of reactive oxygen species-mediated damage to mitochondrial DNA in children with typical autism,” Molecular Autism, vol. 4, article 2, 2013. View at Publisher · View at Google Scholar
  6. A. Chauhan and V. Chauhan, “Oxidative stress in autism,” Pathophysiology, vol. 13, no. 3, pp. 171–181, 2006. View at Publisher · View at Google Scholar · View at Scopus
  7. C. A. Heberling, P. S. Dhurjati, and M. Sasser, “Hypothesis for a systems connectivity model of autism spectrum disorder pathogenesis: link to gut bacteria, oxidative stress, and intestinal permeability,” Medical Hypotheses, vol. 80, no. 3, pp. 264–270, 2013. View at Publisher · View at Google Scholar
  8. S. S. Zoroglu, F. Armutcu, S. Ozen et al., “Increased oxidative stress and altered activities of erythrocyte free radical scavenging enzymes in autism,” European Archives of Psychiatry and Clinical Neuroscience, vol. 254, no. 3, pp. 143–147, 2004. View at Publisher · View at Google Scholar · View at Scopus
  9. Y. Al-Gadani, A. El-Ansary, O. Attas, and L. Al-Ayadhi, “Metabolic biomarkers related to oxidative stress and antioxidant status in Saudi autistic children,” Clinical Biochemistry, vol. 42, no. 10-11, pp. 1032–1040, 2009. View at Publisher · View at Google Scholar · View at Scopus
  10. M. Parellada, C. Moreno, K. Mac-Dowell et al., “Plasma antioxidant capacity is reduced in Asperger syndrome,” Journal of Psychiatric Research, vol. 46, no. 3, pp. 394–401, 2012. View at Publisher · View at Google Scholar · View at Scopus
  11. A. Frustaci, M. Neri, A. Cesario et al., “Oxidative stress-related biomarkers in autism: systematic review and meta-analyses,” Free Radical Biology and Medicine, vol. 52, no. 10, pp. 2128–2141, 2012. View at Publisher · View at Google Scholar
  12. O. Yorbik, A. Sayal, C. Akay, D. I. Akbiyik, and T. Sohmen, “Investigation of antioxidant enzymes in children with autistic disorder,” Prostaglandins Leukotrienes and Essential Fatty Acids, vol. 67, no. 5, pp. 341–343, 2002. View at Publisher · View at Google Scholar · View at Scopus
  13. A. Gvozdjakova, B. Mravec, J. Kucharska et al., “Increased ubiquinone concentration after intracerebroventricularly-administered ubiquinol to selected rat brain regions,” General Physiology and Biophysics, vol. 31, no. 4, pp. 469–472, 2012. View at Publisher · View at Google Scholar
  14. E. Schopler, R. J. Reichler, R. F. DeVellis, and K. Daly, “Toward objective classification of childhood autism: Childhood Autism Rating Scale (CARS),” Journal of Autism and Developmental Disorders, vol. 10, no. 1, pp. 91–103, 1980. View at Google Scholar · View at Scopus
  15. D. R. Janero and B. Burghardt, “Thiobarbituric acid-reactive malondialdehyde formation during superoxide-dependent, iron-catalyzed lipid peroxidation: influence of peroxidation conditions,” Lipids, vol. 24, no. 2, pp. 125–131, 1989. View at Google Scholar · View at Scopus
  16. J. K. Lang, K. Gohil, and L. Packer, “Simultaneous determination of tocopherols, ubiquinols, and ubiquinones in blood, plasma, tissue homogenates, and subcellular fractions,” Analytical Biochemistry, vol. 157, no. 1, pp. 106–116, 1986. View at Google Scholar · View at Scopus
  17. J. Kucharska, A. Gvozdjakova, S. Mizera et al., “Participation of coenzyme Q10 in the rejection development of the transplanted heart: a clinical study,” Physiological Research, vol. 47, no. 6, pp. 399–204, 1998. View at Google Scholar
  18. F. Mosca, D. Fattorini, S. Bompadre, and G. P. Littarru, “Assay of coenzyme Q10 in plasma by a single dilution step,” Analytical Biochemistry, vol. 305, no. 1, pp. 49–54, 2002. View at Publisher · View at Google Scholar · View at Scopus
  19. N. A. Meguid, A. A. Dardir, E. R. Abdel-Raouf, and A. Hashish, “Evaluation of oxidative stress in autism: defective antioxidant enzymes and increased lipid peroxidation,” Biological Trace Element Research, vol. 143, no. 1, pp. 58–65, 2011. View at Publisher · View at Google Scholar · View at Scopus
  20. M. Krajcovicova-Kudlackova, M. Valachovicova, C. Mislanova, Z. Hudecova, M. Sustrova, and D. Ostatnikova, “Plasma concentrations of selected antioxidants in autistic children and adolescents,” Bratislavské Lekárske Listy, vol. 110, no. 4, pp. 247–250, 2009. View at Google Scholar · View at Scopus
  21. A. Chauhan, F. Gu, M. M. Essa et al., “Brain region-specific deficit in mitochondrial electron transport chain complexes in children with autism,” Journal of Neurochemistry, vol. 117, no. 2, pp. 209–220, 2011. View at Publisher · View at Google Scholar · View at Scopus
  22. P. A. Filipek, J. Juranek, M. T. Nguyen, C. Cummings, and J. J. Gargus, “Relative carnitine deficiency in autism,” Journal of Autism and Developmental Disorders, vol. 34, no. 6, pp. 615–623, 2004. View at Publisher · View at Google Scholar · View at Scopus
  23. G. Oliveira, L. Diogo, M. Grazina et al., “Mitochondrial dysfunction in autism spectrum disorders: a population-based study,” Developmental Medicine and Child Neurology, vol. 47, no. 3, pp. 185–189, 2005. View at Publisher · View at Google Scholar · View at Scopus
  24. D. A. Rossignol and J. J. Bradstreet, “Evidence of mitochondrial dysfunction in autism and implications for treatment,” American Journal of Biochemistry and Biotechnology, vol. 4, no. 2, pp. 208–217, 2008. View at Google Scholar · View at Scopus
  25. S. M. Srinivasan and A. N. Bhat, “A review of “music and movement” therapies for children with autism: embodied interventions for multisystem development,” Frontiers in Integrative Neuroscience, vol. 7, article 22, 2013. View at Publisher · View at Google Scholar
  26. D. A. Rossignol, “Novel and emerging treatments for autism spectrum disorders: a systematic review,” Annals of Clinical Psychiatry, vol. 21, no. 4, pp. 213–236, 2009. View at Google Scholar · View at Scopus
  27. A. Gvozdjakova, J. Kucharska, K. Babinska et al., “Effect of ubiquinol on oxidative stress, antioxidants and psychological manifestations in children with autism,” in Proceedings of the 7th Conference of the International Coenzyme Q10 Association, Seville, Spain, November 2012.