Endogenous Ceramide Contributes to the Transcytosis of oxLDL across Endothelial Cells and Promotes Its Subendothelial Retention in Vascular Wall

Figure 2

oxLDL transcytosis in the absence or presence of various inhibitors. HUVECs were incubated with 30 μM MYR, 10 μM DES, 30 μM D609, or 10 μM NOE for 12 h and FITC-oxLDL (50 μg/mL) or oxLDL (300 μg/mL) for 3 h. ^∗𝑃<0.05, ^∗∗𝑃<0.01 versus control, 𝑛=4.