Endogenous Ceramide Contributes to the Transcytosis of oxLDL across Endothelial Cells and Promotes Its Subendothelial Retention in Vascular Wall

Figure 5

Fluorescence microscopic analysis of FITC-oxLDL retention in mouse aortic root. (a) Representative fluorescence microscopic images of aortic root sections of C57 mice after injection with FITC-oxLDL (50 μg/mouse). Scale bars are equal to 500 μm. Top-right panels, pictures with colocalization with DAPI. “Naïve oxLDL” group mice were injected with unlabeled oxLDL. (b) Quantification of FITC fluorescence intensity. ^∗𝑃<0.05 versus control, 𝑛=4.

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