Exercise-Induced Neuroprotection of Hippocampus in APP/PS1 Transgenic Mice via Upregulation of Mitochondrial 8-Oxoguanine DNA Glycosylase

Figure 1

Effects of 20 weeks of treadmill exercise training on behavioral functions: (a) spontaneous alternation behavior; (b) total number of arm entries; (c) retention latency time. SED-Wt: sedentary wild-type mice. EXE-Wt: exercise-trained wild-type mice. SED-Tg: sedentary APP/PS1 transgenic mice. EXE-Tg: exercise-trained APP/PS1 transgenic mice. for all independent experiments. Data are mean ± SD. , compared to SED-WT group. ; , compared to SED-Wt or SED-Tg group. n.s., nonsignificant.

(a)

(b)

(c)