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Oxidative Medicine and Cellular Longevity
Volume 2014 (2014), Article ID 897296, 9 pages
http://dx.doi.org/10.1155/2014/897296
Research Article

Psoralea corylifolia L. Seed Extract Ameliorates Streptozotocin-Induced Diabetes in Mice by Inhibition of Oxidative Stress

1College of Pharmacy and Gachon Institute of Pharmaceutical Science, Gachon University, Incheon 406-840, Republic of Korea
2Lee Gil Ya Cancer and Diabetes Institute, Gachon University, Incheon 406-840, Republic of Korea
3Nanomol Inc. and Regen Phoenix R&D Institute, Incheon 406-840, Republic of Korea
4KM-Based Herbal Drug Research Group, Korea Institute of Oriental Medicine, Daejeon 305-811, Republic of Korea
5Gachon Medical Research Institute, Gil Hospital, Incheon 405-760, Republic of Korea

Received 26 December 2013; Revised 4 March 2014; Accepted 8 March 2014; Published 3 April 2014

Academic Editor: Felipe Dal-Pizzol

Copyright © 2014 Eunhui Seo et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Pancreatic beta-cell death is known to be the cause of deficient insulin production in diabetes mellitus. Oxidative stress is one of the major causes of beta-cell death. In this study, we investigated the effects of Psoralea corylifolia L. seed (PCS) extract on beta-cell death. Oral administration of PCS extract resulted in a significant improvement of hyperglycemia in streptozotocin-induced diabetic mice. PCS extract treatment improved glucose tolerance and increased serum insulin levels. To study the mechanisms involved, we investigated the effects of PCS extract on H2O2-induced apoptosis in INS-1 cells. Treatment with PCS extract inhibited cell death. PCS extract treatment decreased reactive oxygen species level and activated antioxidative enzymes. Among the major components of PCS extract, psoralen and isopsoralen (coumarins), but not bakuchiol, showed preventive effects against H2O2-induced beta-cell death. These findings indicate that PCS extract may be a potential pharmacological agent to protect against pancreatic beta-cell damage caused by oxidative stress associated with diabetes.