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Oxidative Medicine and Cellular Longevity
Volume 2014, Article ID 906965, 13 pages
Review Article

Global Consequences of Liver Ischemia/Reperfusion Injury

1Second Department of Surgery, School of Medicine, Aretaieion University Hospital, University of Athens, 76 Vassilisis Sofia’s Avenue, 11528 Athens, Greece
2Second Department of Anesthesiology, School of Medicine, Attikon University Hospital, University of Athens, 1 Rimini Street, 12462 Athens, Greece
3Division of Surgery & Interventional Sciences, Royal Free Hospital Campus, University College London, 8 South Pond Street, Hampstead, London NW3 2QG, UK
4First Department of Anesthesiology, Aretaieion Hospital, University of Athens School of Medicine, Vassilissis Sofias 76, 11528 Athens, Greece
5Fourth Department of Surgery, School of Medicine, Attikon University Hospital, University of Athens, 1 Rimini Street, 12462 Athens, Greece

Received 21 August 2013; Revised 2 January 2014; Accepted 13 January 2014; Published 1 April 2014

Academic Editor: Mengzhou Xue

Copyright © 2014 Constantinos Nastos et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Liver ischemia/reperfusion injury has been extensively studied during the last decades and has been implicated in the pathophysiology of many clinical entities following hepatic surgery and transplantation. Apart from its pivotal role in the pathogenesis of the organ’s post reperfusion injury, it has also been proposed as an underlying mechanism responsible for the dysfunction and injury of other organs as well. It seems that liver ischemia and reperfusion represent an event with “global” consequences that influence the function of many remote organs including the lung, kidney, intestine, pancreas, adrenals, and myocardium among others. The molecular and clinical manifestation of these remote organs injury may lead to the multiple organ dysfunction syndrome, frequently encountered in these patients. Remote organ injury seems to be in part the result of the oxidative burst and the inflammatory response following reperfusion. The present paper aims to review the existing literature regarding the proposed mechanisms of remote organ injury after liver ischemia and reperfusion.