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Oxidative Medicine and Cellular Longevity
Volume 2014, Article ID 920676, 10 pages
http://dx.doi.org/10.1155/2014/920676
Research Article

Circulating Levels of Sirtuin 4, a Potential Marker of Oxidative Metabolism, Related to Coronary Artery Disease in Obese Patients Suffering from NAFLD, with Normal or Slightly Increased Liver Enzymes

1Department of Clinical Medicine and Surgery, Federico II University Medical School of Naples, Via Sergio Pansini 5, 80131 Naples, Italy
2Centro Ricerche Oncologiche di Mercogliano, Istituto Nazionale Per Lo Studio E La Cura Dei Tumori “Fondazione Giovanni Pascale”, IRCCS, 83013 Mercogliano, Italy
3Center of Obesity and Eating Disorders, Stella Maris Mediterraneum Foundation, C/da Santa Lucia, Chiaromonte, 80035 Potenza, Italy
4Department of Biochemistry and Medical Biotechnology, Federico II University Medical School of Naples, Via Sergio Pansini 5, 80131 Naples, Italy
5Department of Neuroscience, Unit of Clinical Pharmacology, Federico II University Medical School of Naples, Via Sergio Pansini 5, 80131 Naples, Italy

Received 23 January 2014; Accepted 23 May 2014; Published 17 June 2014

Academic Editor: Tomas Mracek

Copyright © 2014 Giovanni Tarantino et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. H. Zhang, C. Xie, H. J. Spencer et al., “Obesity and hepatosteatosis in mice with enhanced oxidative DNA damage processing in mitochondria,” American Journal of Pathology, vol. 178, no. 4, pp. 1715–1727, 2011. View at Publisher · View at Google Scholar · View at Scopus
  2. N. Nasrin, X. Wu, E. Fortier et al., “SIRT4 regulates fatty acid oxidation and mitochondrial gene expression in liver and muscle cells,” Journal of Biological Chemistry, vol. 285, no. 42, pp. 31995–32002, 2010. View at Publisher · View at Google Scholar · View at Scopus
  3. M. C. Haigis, R. Mostoslavsky, K. M. Haigis et al., “SIRT4 inhibits glutamate dehydrogenase and opposes the effects of calorie restriction in pancreatic beta cells,” Cell, vol. 126, no. 5, pp. 941–954, 2006. View at Publisher · View at Google Scholar · View at Scopus
  4. N. Ahuja, B. Schwer, S. Carobbio et al., “Regulation of insulin secretion by SIRT4, a mitochondrial ADP-ribosyltransferase,” Journal of Biological Chemistry, vol. 282, no. 46, pp. 33583–33592, 2007. View at Publisher · View at Google Scholar · View at Scopus
  5. Y.-R. Chen, S.-R. Fang, Y.-C. Fu, X.-H. Zhou, M.-Y. Xu, and W.-C. Xu, “Calorie restriction on insulin resistance and expression of SIRT1 and SIRT4 in rats,” Biochemistry and Cell Biology, vol. 88, no. 4, pp. 715–722, 2010. View at Google Scholar · View at Scopus
  6. R. Song, W. Xu, Y. Chen, Z. Li, Y. Zeng, and Y. Fu, “The expression of Sirtuins 1 and 4 in peripheral blood leukocytes from patients with type 2 diabetes,” European Journal of Histochemistry, vol. 55, no. 1, article e10, 2011. View at Google Scholar · View at Scopus
  7. G. Tarantino, G. Saldalamacchia, P. Conca, and A. Arena, “Non-alcoholic fatty liver disease: further expression of the metabolic syndrome,” Journal of Gastroenterology and Hepatology, vol. 22, no. 3, pp. 293–303, 2007. View at Publisher · View at Google Scholar · View at Scopus
  8. R. Chhabra, J.H. O'Keefe, H. Patil et al., “Association of coronary artery calcification with hepatic steatosis in asymptomatic individuals,” Mayo Clinic Proceedings, vol. 88, pp. 1259–1265, 2013. View at Google Scholar
  9. B. H. Goodpaster and D. Wolf, “Skeletal muscle lipid accumulation in obesity, insulin resistance, and type 2 diabetes,” Pediatric Diabetes, vol. 5, no. 4, pp. 219–226, 2004. View at Publisher · View at Google Scholar · View at Scopus
  10. V. K. Mootha, C. M. Lindgren, K.-F. Eriksson et al., “PGC-1α-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes,” Nature Genetics, vol. 34, no. 3, pp. 267–273, 2003. View at Publisher · View at Google Scholar · View at Scopus
  11. S. Pillen, I. M. P. Arts, and M. J. Zwarts, “Muscle ultrasound in neuromuscular disorders,” Muscle and Nerve, vol. 37, no. 6, pp. 679–693, 2008. View at Publisher · View at Google Scholar · View at Scopus
  12. R. Fathi and T. H. Marwick, “Noninvasive tests of vascular function and structure: why and how to perform them,” American Heart Journal, vol. 141, no. 5, pp. 694–703, 2001. View at Publisher · View at Google Scholar · View at Scopus
  13. E. L. B. Novelli, G. A. Souza, G. M. X. Ebaid et al., “Energy expenditure and oxygen consumption as novel biomarkers of obesity-induced cardiac disease in rats,” Obesity, vol. 18, no. 9, pp. 1754–1761, 2010. View at Publisher · View at Google Scholar · View at Scopus
  14. G. Tarantino, M. Marra, F. Contaldo, and F. Pasanisi, “Basal metabolic rate in morbidly obese patients with non-alcoholic fatty liver disease,” Clinical and Investigative Medicine, vol. 31, no. 1, pp. E24–E29, 2008. View at Google Scholar · View at Scopus
  15. Y. Schutz, U. U. G. Kyle, and C. Pichard, “Fat-free mass index and fat mass index percentiles in caucasians aged 18–98 y,” International Journal of Obesity, vol. 26, no. 7, pp. 953–960, 2002. View at Publisher · View at Google Scholar · View at Scopus
  16. G. Tarantino, P. Colicchio, P. Conca et al., “Young adult obese subjects with and without insulin resistance: what is the role of chronic inflammation and how to weigh it non-invasively?” Journal of Inflammation, vol. 6, article 6, 2009. View at Publisher · View at Google Scholar · View at Scopus
  17. M. Webb, H. Yeshua, S. Zelber-Sagi et al., “Diagnostic value of a computerized hepatorenal index for sonographic quantification of liver steatosis,” American Journal of Roentgenology, vol. 192, no. 4, pp. 909–914, 2009. View at Publisher · View at Google Scholar · View at Scopus
  18. J. Z. Heckmatt, S. Leeman, and V. Dubowitz, “Ultrasound imaging in the diagnosis of muscle disease,” Journal of Pediatrics, vol. 101, no. 5, pp. 656–660, 1982. View at Google Scholar · View at Scopus
  19. G. Tarantino, C. Finelli, A. Colao et al., “Are hepatic steatosis and carotid intima media thickness associated in obese patients with normal or slightly elevated gamma-glutamyl-transferase?” Journal of Translational Medicine, vol. 10, no. 1, article 50, 2012. View at Publisher · View at Google Scholar · View at Scopus
  20. R. S. Rector, J. P. Thyfault, G. M. Uptergrove et al., “Mitochondrial dysfunction precedes insulin resistance and hepatic steatosis and contributes to the natural history of non-alcoholic fatty liver disease in an obese rodent model,” Journal of Hepatology, vol. 52, no. 5, pp. 727–736, 2010. View at Publisher · View at Google Scholar · View at Scopus
  21. K. Begriche, A. Igoudjil, D. Pessayre, and B. Fromenty, “Mitochondrial dysfunction in NASH: causes, consequences and possible means to prevent it,” Mitochondrion, vol. 6, no. 1, pp. 1–38, 2006. View at Publisher · View at Google Scholar · View at Scopus
  22. Y. Tsujimoto, T. Nakagawa, and S. Shimizu, “Mitochondrial membrane permeability transition and cell death,” Biochimica et Biophysica Acta, vol. 1757, no. 9-10, pp. 1297–1300, 2006. View at Publisher · View at Google Scholar · View at Scopus
  23. A. Deniaud, O. Sharaf El Dein, E. Maillier et al., “Endoplasmic reticulum stress induces calcium-dependent permeability transition, mitochondrial outer membrane permeabilization and apoptosis,” Oncogene, vol. 27, no. 3, pp. 285–299, 2008. View at Publisher · View at Google Scholar · View at Scopus
  24. A. K. Leamy, R. A. Egnatchik, and J. D. Young, “Molecular mechanisms and the role of saturated fatty acids in the progression of non-alcoholic fatty liver disease,” Progress in Lipid Research, vol. 52, no. 1, pp. 165–174, 2013. View at Publisher · View at Google Scholar · View at Scopus
  25. N. Brustovetsky, T. Brustovetsky, K. J. Purl, M. Capano, M. Crompton, and J. M. Dubinsky, “Increased susceptibility of striatal mitochondria to calcium-induced permeability transition,” Journal of Neuroscience, vol. 23, no. 12, pp. 4858–4867, 2003. View at Google Scholar · View at Scopus
  26. G. Tarantino, S. Savastano, and A. Colao, “Hepatic steatosis, low-grade chronic inflammation and hormone/growth factor/adipokine imbalance,” World Journal of Gastroenterology, vol. 16, no. 38, pp. 4773–4783, 2010. View at Publisher · View at Google Scholar · View at Scopus
  27. D. B. Lombard, D. X. Tishkoff, and J. Bao, “Mitochondrial sirtuins in the regulation of mitochondrial activity and metabolic adaptation,” Handbook of Experimental Pharmacology, vol. 206, pp. 163–188, 2011. View at Publisher · View at Google Scholar · View at Scopus
  28. U. Förstermann, “Nitric oxide and oxidative stress in vascular disease,” Pflugers Archiv European Journal of Physiology, vol. 459, no. 6, pp. 923–939, 2010. View at Publisher · View at Google Scholar · View at Scopus
  29. L. Busetto, P. Perini, V. Giantin et al., “Relationship between energy expenditure and visceral fat accumulation in obese women submitted to adjustable silicone gastric banding (ASGB),” International Journal of Obesity, vol. 19, no. 4, pp. 227–233, 1995. View at Google Scholar · View at Scopus