Olive (Olea europaea) Leaf Extract Induces Apoptosis and Monocyte/Macrophage Differentiation in Human Chronic Myelogenous Leukemia K562 Cells: Insight into the Underlying Mechanism
Table 2
The distribution of cell cycle in K562 cells treated with Chemlali Olive Leaf Extract (COLE).
Day 1
Day 2
Day 3
Day 4
G0/G1
Control
27.63 ± 2.90
24.50 ± 0.45
31.36 ± 1.85
29.83 ± 3.52
100 µg/mL
27.36 ± 4.07
22.56 ± 2.67
27.76 ± 2.09
23.45 ± 3.81
150 µg/mL
39.80 ± 2.26*
31.01 ± 1.3**
20.96 ± 2.78**
12.43 ± 0.64**
S
Control
22.07 ± 1.15
21.07 ± 1.33
17.70 ± 2.1
20.00 ± 1.6
100 µg/mL
27.69 ± 2.59*
22.35 ± 1.83
18.93 ± 0.72
16.15 ± 0.73*
150 µg/mL
14.65 ± 3.58*
24.54 ± 0.6*
18.49 ± 3.47
16.88 ± 2.59
G2/M
Control
33.57 ± 0.98
30.20 ± 1.44
27.93 ± 1.36
28.60 ± 0.7
100 µg/mL
24.41 ± 2.27**
36.97 ± 1.6**
32.47 ± 1.1*
36.11 ± 2.64**
150 µg/mL
18.93 ± 0.54**
27.72 ± 2.07
37.25 ± 2.1**
34.00 ± 1.83**
Results are represented as the means ± SD of three independent experiments. * and ** mean that difference between control and treated cells in each phase (G0/G1, S and G2/M) is statistically significant at and , respectively.
