Ovarian Aging-Like Phenotype in the Hyperandrogenism-Induced Murine Model of Polycystic Ovary

Table 1

Comparative assessment of weight and histopathological changes of ovary in experimental and control groups.

	Control	PCO
Body weight (g)	231.2±1.11	249.8±0.81^∗∗∗
Ovary weight (g)	0.044±0.002	0.06±0.002^∗∗∗
Luteinization of follicular wall and granulosa cells	—	+++
Vascularization of follicular wall	—	+++
Degenerated and deformed oocyte	—	+++
Pyknosis and chromatinization of granulosa cells	—	+++
Disintegration and dispersion of granulosa cells	—	+++
Hyperplasia of theca cells	—	+++
Breakdown and fragmentation of ZP	—	++

∗represents a significant difference between control and PCO groups.
The symbols represent statistical significance: ^∗𝑃<0.05, **𝑃<0.01, and ***𝑃<0.001.
Intensity of the histopathological changes: (—) no change; (+) slight change; (++); marked change; (+++) sever change.