Urinary Excretion of Neutrophil Gelatinase-Associated Lipocalin in Diabetic Rats
Figure 7
(a)–(f) are representative microphotographs of cortical kidney sections stained with hematoxylin/eosin. (a)–(c) From animals sacrificed 7 days after diabetes induction and (d)–(f) from animals euthanized 30 days after induction. (a) and (d) Kidneys from control rats show no lesions. (b) Diabetic animal (7 days) exhibits tubular epithelium vacuolar degeneration (arrows). (e) Diabetic rat (30 days) shows vacuolization (arrows), detachment, and debris of the tubular epithelial cells in the tubular lumen (arrowheads). (c) and (f) Diabetic insulin treated rats, with no abnormalities and considerable attenuation of these changes, respectively. (200x original magnification).
