Panaxatriol Saponins Attenuated Oxygen-Glucose Deprivation Injury in PC12 Cells via Activation of PI3K/Akt and Nrf2 Signaling Pathway
Figure 2
Cytotoxicity and protective effect of PTS, Rg1, Re, and R1 in PC12 cells. (a) Cytotoxicity of PTS. PC12 cells were treated with PTS at concentrations ranging from 0 to 40 μg·mL−1 for 24 h. (b) Cytotoxicity of Rg1, Re, and R1. The treatment was the same as described in Panel A except with the indicated concentrations. (c) Effect of PTS on the cell survival of PC12 cells against OGD-Rep. PC12 cells were pretreated with PTS at concentrations ranging from 0 to 20 μg·mL−1 or the combination of Rg1, Re, and R1 (Comb.) with each 2.5 μM for 2 h, subsequently subjected to OGD-Rep treatment for 8 h, and finally maintained in oxygenated cell culture medium for another 24 h. The cell viability was determined by CCK-8 assay. Values represent mean ± SD (). and versus OGD-Rep.
