Review Article

Controlling Redox Status for Stem Cell Survival, Expansion, and Differentiation

Figure 4

Modulation of ROS level regulates the stem cell fate decision. ROS play dual role in stem cell homeostasis, depending on its level of production. At mild levels, ROS serves as a secondary physiological messenger. At high levels, ROS is a source of oxidative stress that leads to cell apoptosis. Tight regulation of biochemical and biomechanical environment can control stem cell oxidative status and thus the stem cell fate decision.