Research Article

High Potency of a Novel Resveratrol Derivative, 3,3′,4,4′-Tetrahydroxy-trans-stilbene, against Ovarian Cancer Is Associated with an Oxidative Stress-Mediated Imbalance between DNA Damage Accumulation and Repair

Table 3

Effect of RVT and 3,3′,4,4′-THS on the biological properties of HOSE cells and HPMCs. The results are expressed as a percentage of values obtained for control cells that were not subjected to RVT and 3,3′,4,4′-THS. The results derive from experiments performed in octuplicate with HOSE cells and from studies with HPMCs from 8 different donors. The asterisks indicate a significant difference as compared to the control group. The hashes indicate a significant difference as compared to cells exposed to an equimolar concentration of RVT.

CellsHOSE cellsHPMCs
StilbeneRVT3,3′,4,4′-THSRVT3,3′,4,4′-THS
Dose10 μM50 μM100 μM10 μM50 μM100 μM10 μM50 μM100 μM10 μM50 μM100 μM

ROS103 ± 3105 ± 4121 ± 775 ± 472 ± 399 ± 4#108 ± 4106 ± 11105 ± 7104 ± 4102 ± 382 ± 1
SOD111 ± 3112 ± 3121 ± 4122 ± 1141 ± 5136 ± 2110 ± 2112 ± 3113 ± 2122 ± 4141 ± 3136 ± 4
CAT121 ± 6119 ± 4121 ± 6132 ± 1163 ± 4162 ± 1101 ± 1103 ± 4118 ± 3112 ± 2123 ± 4154 ± 1
8-OH-dG103 ± 5102 ± 582 ± 4103 ± 376 ± 371 ± 2103 ± 3103 ± 2102 ± 591 ± 288 ± 376 ± 3
Apoptosis99 ± 2101 ± 2102 ± 3101 ± 1100 ± 2102 ± 2101 ± 1101 ± 198 ± 398 ± 2102 ± 2100 ± 4
Proliferation103 ± 4102 ± 1104 ± 2116 ± 2103 ± 199 ± 599 ± 3103 ± 4102 ± 2141 ± 3103 ± 1102 ± 2
SA--Gal101 ± 2101 ± 2100 ± 399 ± 2101 ± 3102 ± 5100 ± 2102 ± 4100 ± 176 ± 3104 ± 499 ± 3
p38 MAPK103 ± 5107 ± 10108 ± 11106 ± 5104 ± 4100 ± 3113 ± 16103 ± 2105 ± 782 ± 381 ± 6104 ± 2