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Oxidative Medicine and Cellular Longevity
Volume 2015, Article ID 150829, 10 pages
http://dx.doi.org/10.1155/2015/150829
Research Article

Tocotrienol Rich Palm Oil Extract Is More Effective Than Pure Tocotrienols at Improving Endothelium-Dependent Relaxation in the Presence of Oxidative Stress

School of Medical Sciences, Health Innovations Research Institute, RMIT University, Bundoora, VIC 3083, Australia

Received 5 January 2015; Revised 24 April 2015; Accepted 24 April 2015

Academic Editor: Giuseppe Cirillo

Copyright © 2015 Saher F. Ali and Owen L. Woodman. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. B. B. Aggarwal, C. Sundaram, S. Prasad, and R. Kannappan, “Tocotrienols, the vitamin E of the 21st century: its potential against cancer and other chronic diseases,” Biochemical Pharmacology, vol. 80, no. 11, pp. 1613–1631, 2010. View at Publisher · View at Google Scholar · View at Scopus
  2. R. A. Parker, B. C. Pearce, R. W. Clark, D. A. Gordon, and J. J. K. Wright, “Tocotrienols regulate cholesterol production in mammalian cells by post- transcriptional suppression of 3-hydroxy-3-methylglutaryl-coenzyme A reductase,” Journal of Biological Chemistry, vol. 268, no. 15, pp. 11230–11238, 1993. View at Google Scholar · View at Scopus
  3. A. J. Esterhuyse, E. F. du Toit, A. J. S. Benadeè, and J. van Rooyen, “Dietary red palm oil improves reperfusion cardiac function in the isolated perfused rat heart of animals fed a high cholesterol diet,” Prostaglandins Leukotrienes and Essential Fatty Acids, vol. 72, no. 3, pp. 153–161, 2005. View at Publisher · View at Google Scholar · View at Scopus
  4. M. Berbee, Q. Fu, M. Boerma et al., “Reduction of radiation-induced vascular nitrosative stress by the vitamin e analog γ-tocotrienol: evidence of a role for tetrahydrobiopterin,” International Journal of Radiation Oncology, Biology, Physics, vol. 79, no. 3, pp. 884–891, 2011. View at Publisher · View at Google Scholar · View at Scopus
  5. M. A. Newaz, Z. Yousefipour, N. Nawal, and N. Adeeb, “Nitric oxide synthase activity in blood vessels of spontaneously hypertensive rats: antioxidant protection by gamma-tocotrienol,” Journal of Physiology and Pharmacology, vol. 54, no. 3, pp. 319–327, 2003. View at Google Scholar
  6. A. Kuhad and K. Chopra, “Tocotrienol attenuates oxidative-nitrosative stress and inflammatory cascade in experimental model of diabetic neuropathy,” Neuropharmacology, vol. 57, no. 4, pp. 456–462, 2009. View at Publisher · View at Google Scholar
  7. K.-Z. Norsidah, A. Y. Asmadi, A. Azizi, O. Faizah, and Y. Kamisah, “Palm tocotrienol-rich fraction improves vascular proatherosclerotic changes in hyperhomocysteinemic rats,” Evidence-Based Complementary and Alternative Medicine, vol. 2013, Article ID 976967, 10 pages, 2013. View at Publisher · View at Google Scholar · View at Scopus
  8. S. P. Muharis, A. G. M. Top, D. Murugan, and M. R. Mustafa, “Palm oil tocotrienol fractions restore endothelium dependent relaxation in aortic rings of streptozotocin-induced diabetic and spontaneously hypertensive rats,” Nutrition Research, vol. 30, no. 3, pp. 209–216, 2010. View at Publisher · View at Google Scholar · View at Scopus
  9. S. B. Budin, F. Othman, S. R. Louis, M. A. Bakar, S. Das, and J. Mohamed, “The effects of palm oil tocotrienol-rich fraction supplementation on biochemical parameters, oxidative stress and the vascular wall of streptozotocin-induced diabetic rats,” Clinics, vol. 64, no. 3, pp. 235–244, 2009. View at Google Scholar · View at Scopus
  10. A. H. G. Rasool, A. R. A. Rahman, K. H. Yuen, and A. R. Wong, “Arterial compliance and vitamin E blood levels with a self emulsifying preparation of tocotrienol rich vitamin E,” Archives of Pharmacal Research, vol. 31, no. 9, pp. 1212–1217, 2008. View at Publisher · View at Google Scholar · View at Scopus
  11. C.-H. Leo, J. L. Hart, and O. L. Woodman, “3′,4′-dihydroxyflavonol restores endothelium-dependent relaxation in small mesenteric artery from rats with type 1 and type 2 diabetes,” European Journal of Pharmacology, vol. 659, no. 2-3, pp. 193–198, 2011. View at Publisher · View at Google Scholar · View at Scopus
  12. C. H. Leo, A. Joshi, and O. L. Woodman, “Short-term type 1 diabetes alters the mechanism of endothelium-dependent relaxation in the rat carotid artery,” The American Journal of Physiology—Heart and Circulatory Physiology, vol. 299, no. 2, pp. H502–H511, 2010. View at Publisher · View at Google Scholar · View at Scopus
  13. Y. Saito, K. Nishio, Y. O. Akazawa et al., “Cytoprotective effects of vitamin E homologues against glutamate-induced cell death in immature primary cortical neuron cultures: Tocopherols and tocotrienols exert similar effects by antioxidant function,” Free Radical Biology and Medicine, vol. 49, no. 10, pp. 1542–1549, 2010. View at Publisher · View at Google Scholar · View at Scopus
  14. Y. Saito, Y. Yoshida, T. Akazawa, K. Takahashi, and E. Niki, “Cell death caused by selenium deficiency and protective effect of antioxidants,” Journal of Biological Chemistry, vol. 278, no. 41, pp. 39428–39434, 2003. View at Publisher · View at Google Scholar · View at Scopus
  15. Y. Saito, Y. Yoshida, K. Nishio, M. Hayakawa, and E. Niki, “Characterization of cellular uptake and distribution of vitamin E,” Annals of the New York Academy of Sciences, vol. 1031, pp. 368–375, 2004. View at Publisher · View at Google Scholar · View at Scopus
  16. E. C. H. Chan, G. R. Drummond, and O. L. Woodman, “3, 4-dihydroxyflavonol enhances nitric oxide bioavailability and improves vascular function after ischemia and reperfusion injury in the rat,” Journal of Cardiovascular Pharmacology, vol. 42, no. 6, pp. 727–735, 2003. View at Publisher · View at Google Scholar · View at Scopus
  17. L. J. Ignarro, R. E. Byrns, G. M. Buga, K. S. Wood, and G. Chaudhuri, “Pharmacological evidence that endothelium-derived relaxing factor is nitric oxide: use of pyrogallol and superoxide dismutase to study endothelium-dependent and nitric oxide-elicited vascular smooth muscle relaxation,” The Journal of Pharmacology and Experimental Therapeutics, vol. 244, no. 1, pp. 181–189, 1988. View at Google Scholar · View at Scopus
  18. A. Ellis, C. G. Li, and M. J. Rand, “Effect of xanthine oxidase inhibition on endothelium-dependent and nitrergic relaxations,” European Journal of Pharmacology, vol. 356, no. 1, pp. 41–47, 1998. View at Publisher · View at Google Scholar · View at Scopus
  19. N. Cantu-Medellin and E. E. Kelley, “Xanthine oxidoreductase-catalyzed reactive species generation: a process in critical need of reevaluation,” Redox Biology, vol. 1, no. 1, pp. 353–358, 2013. View at Publisher · View at Google Scholar · View at Scopus
  20. M.-C. Desco, M. Asensi, R. Márquez et al., “Xanthine oxidase is involved in free radical production in type 1 diabetes: protection by allopurinol,” Diabetes, vol. 51, no. 4, pp. 1118–1124, 2002. View at Publisher · View at Google Scholar · View at Scopus
  21. A. Kamal-Eldin and L.-Å. Appelqvist, “The chemistry and antioxidant properties of tocopherols and tocotrienols,” Lipids, vol. 31, no. 7, pp. 671–701, 1996. View at Publisher · View at Google Scholar · View at Scopus
  22. Y. Yoshida, E. Niki, and N. Noguchi, “Comparative study on the action of tocopherols and tocotrienols as antioxidant: chemical and physical effects,” Chemistry and Physics of Lipids, vol. 123, no. 1, pp. 63–75, 2003. View at Publisher · View at Google Scholar · View at Scopus
  23. R. Kissner, T. Nauser, P. Bugnon, P. G. Lye, and W. H. Koppenol, “Formation and properties of peroxynitrite as studied by laser flash photolysis, high-pressure stopped-flow technique, and pulse radiolysis,” Chemical Research in Toxicology, vol. 10, no. 11, pp. 1285–1292, 1997. View at Publisher · View at Google Scholar
  24. G. Ferrer-Sueta, C. Quijano, B. Alvarez, and R. Radi, “Reactions of manganese porphyrins and manganese-superoxide dismutase with peroxynitrite,” Methods in Enzymology, vol. 349, pp. 23–37, 2002. View at Publisher · View at Google Scholar · View at Scopus
  25. T. S. Jackson, A. Xu, J. A. Vita, and J. F. Keaney Jr., “Ascorbate prevents the interaction of superoxide and nitric oxide only at very high physiological concentrations,” Circulation Research, vol. 83, no. 9, pp. 916–922, 1998. View at Google Scholar
  26. N. Gotoh and E. Niki, “Rates of interactions of superoxide with vitamin E, vitamin C and related compounds as measured by chemiluminescence,” Biochimica et Biophysica Acta, vol. 1115, no. 3, pp. 201–207, 1992. View at Publisher · View at Google Scholar · View at Scopus
  27. G. Upadhyay, S. P. Gupta, O. Prakash, and M. P. Singh, “Pyrogallol-mediated toxicity and natural antioxidants: triumphs and pitfalls of preclinical findings and their translational limitations,” Chemico-Biological Interactions, vol. 183, no. 3, pp. 333–340, 2010. View at Publisher · View at Google Scholar · View at Scopus
  28. H. Ahsan, A. Ahad, J. Iqbal, and W. A. Siddiqui, “Pharmacological potential of tocotrienols: a review,” Nutrition & Metabolism, vol. 11, no. 1, article 52, 2014. View at Publisher · View at Google Scholar