Cyclovirobuxine D Attenuates Doxorubicin-Induced Cardiomyopathy by Suppression of Oxidative Damage and Mitochondrial Biogenesis Impairment

Figure 2

Light micrograph demonstrating the effect of CVB-D on DOX-induced myocardial histological alterations. Representative photomicrographs of mouse heart stained with H&E. (a) Normal saline-treated control; (b) CVB-D pretreated group; (c) DOX-treated group; (d) CVB-D plus DOX-treated group. Arrows indicate areas of histological changes including reduced myofibrils, swelling, vacuolization, and nuclear condensation or dissolution. Scale bar = 20 μm.

(a)

(b)

(c)

(d)