Tau Hyperphosphorylation and Oxidative Stress, a Critical Vicious Circle in Neurodegenerative Tauopathies?

Table 1

Major pathogenic tau mutations.

Mutation	Type	Effect	Reference
P301L	Substitution	Neuronal impairment, NFT formation	Vogelsberg-Ragaglia, et al., 2000 [94]
P301S	Substitution	Tau hyperphosphorylation and aggregation	Bugiani et al., 1999 [95]
ΔK280	Deletion	Tau aggregation and decreased microtubule affinity, neural loss	Vogelsberg-Ragaglia, et al., 2000 [94]
VPR triple mutant (R406W, P301L, and V337M)	Substitution	Tau hyperphosphorylation, aggregation, and decreased microtubule affinity	Tatebayashi, et al., 2002 [96]; Tanemura, et al., 2002 [97]
N296N	Silent	Greater 4R to 3R ratio (splicing)	Spillantini, et al., 2000 [98]