Selective Nitric Oxide Synthase Inhibitor 7-Nitroindazole Protects against Cocaine-Induced Oxidative Stress in Rat Brain

Table 1

Quantitative assessment of some behavioral changes observed 24 hours after the last administration of cocaine and 7-NI.

Behavioral changes	Control	Cocaine	7-NI	7-NI + cocaine
Decreased locomotor activity	−	++	−	−
Excitation	−	++	−	−
Changes in coordination	−	−	−	−
Salivation	−	+++	−	+
Respiration-enhanced breathing	−	+++	−	+

(for each treatment group).
+++ means severe; ++ means moderate; + means slight; − means no effect.
Observations were performed 24 hours after the last administration of the compounds. The symptoms were observed for 30 min. The observations and changes were recorded on the basis of the standardized observation grid, derived from that of Irwin test [15], adjusted to the conditions and objectives of our study.