Propofol Attenuates Small Intestinal Ischemia Reperfusion Injury through Inhibiting NADPH Oxidase Mediated Mast Cell Activation

Figure 4

Survival rates and morphological changes of intestine and intestinal histological score under light microscope after IIR. SHAM group (Sham-operated group), IIR group (75 min intestinal ischemia and 2 h reperfusion), and IIR + CP group (IIR group + Compound 48/80 1 mg/kg) in the absence or presence of NAC (0.5 g/kg) or propofol (50 mg/kg) or intralipid (50 mg/kg). ((a)–(c)) Survival rats in rats subjected to IIR with or without NAC, propofol, or intralipid pretreatment. Results are expressed as percentage of live animals, per group, whereas in IIR + CP group and IIR + CP + intralipid group. (d) Representative images of HE staining (×200). Black arrow: lamina propria villus shedding. Red arrow: engorgement of capillary vessel. White arrow: top villus shedding. (e) quantified the intestine histological scores. Results are expressed as Mean ± SEM. per group, whereas in IIR + CP group. versus SHAM group, versus IIR group, versus IIR + CP group, versus IIR with NAC pretreated group, versus IIR with propofol pretreated group, and versus IIR with intralipid pretreated group.

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