Propofol Attenuates Small Intestinal Ischemia Reperfusion Injury through Inhibiting NADPH Oxidase Mediated Mast Cell Activation

Figure 5

Changes of SOD activities, 15--isoprostane contents, p4 protein expression, gp9, P-selectin, and ICAM-1 protein expressions, IL-6 levels, and MPO activities in intestine mucosa after IIR injury. SHAM group (Sham-operated group), IIR group (75 min intestinal ischemia and 2 h reperfusion), and IIR + CP group (IIR group + Compound 48/80 1 mg/kg) in the absence or presence of NAC (0.5 g/kg), propofol (50 mg/kg), intralipid (50 mg/kg). (a) SOD activities, (b) 15--isoprostane contents in intestine (, except in IIR + CP group). ((c) and (d)) p4 and gp9 protein expressions, respectively (), ((e) and (f)) IL-6 levels and MPO activities in intestinal mucosa (, except in IIR + CP group). ((g) and (h)) ICAM-1 and P-selectin protein expressions, respectively (). Results are expressed as Mean ± SEM. versus SHAM group, versus IIR group, versus IIR + CP group, versus IIR with NAC pretreated group, versus IIR with propofol pretreated group, and versus IIR with intralipid pretreated group.

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