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Oxidative Medicine and Cellular Longevity
Volume 2015, Article ID 186908, 16 pages
Review Article

Role of Hydrogen Sulfide in Ischemia-Reperfusion Injury

1Medical College of Henan University, Kaifeng, Henan 475004, China
2Department of Neurology, Institute of Neurological Disorders, The First Affiliated Hospital of Henan University, Kaifeng 475001, China

Received 17 October 2014; Revised 10 December 2014; Accepted 10 December 2014

Academic Editor: Guangdong Yang

Copyright © 2015 Dongdong Wu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Ischemia-reperfusion (I/R) injury is one of the major causes of high morbidity, disability, and mortality in the world. I/R injury remains a complicated and unresolved situation in clinical practice, especially in the field of solid organ transplantation. Hydrogen sulfide (H2S) is the third gaseous signaling molecule and plays a broad range of physiological and pathophysiological roles in mammals. H2S could protect against I/R injury in many organs and tissues, such as heart, liver, kidney, brain, intestine, stomach, hind-limb, lung, and retina. The goal of this review is to highlight recent findings regarding the role of H2S in I/R injury. In this review, we present the production and metabolism of H2S and further discuss the effect and mechanism of H2S in I/R injury.