Saraca indica Bark Extract Shows In Vitro Antioxidant, Antibreast Cancer Activity and Does Not Exhibit Toxicological Effects
Table 3
Result of serum biochemical analysis on day 15 of oral gavage administration of 500, 1000, 1500, and 2000 mg/Kg B.Wt. of SIE to female CF rats. NS represents the no statistical differences, when the test groups were compared to the control group.
Parameter
Control group
500 mg/Kg B.Wt.
1000 mg/Kg B.Wt.
1500 mg/Kg B.Wt.
2000 mg/Kg B.Wt.
value
Mean
±SD
Mean
±SD
Mean
±SD
Mean
±SD
Mean
±SD
1
UREA
27.6
2.094
37.48
5.53
34.6
9.361
27.92
2.172
31.02
5.005
NS
2
ALT
69.4
14.049
87.64
27.677
72.22
11.336
65.44
7.158
58.62
8.545
NS
3
AST
227.76
18.709
249.92
20.422
273.9
23.13
233.68
37.570
222.28
38.749
NS
4
ALP
785.3
107.7
725.60
187.7
728.80
46.32
711.80
102.20
741.6
117.10
NS
5
TG
35.56
9.916
38.48
10.185
42.24
9.333
39.3
3.903
46.26
11.007
NS
6
TCHO
58.9
10.342
62.9
6.264
65.32
27.640
60.38
7.960
55.36
11.083
NS
7
TP
6.958
0.370
7.558
0.585
7.722
1.865
7.41
0.208
7.344
0.368
NS
8
ALB
3.358
0.138
3.574
0.277
3.84
30.315
3.518
0.216
3.528
0.207
NS
9
GLU
144.56
32.497
167.16
98.128
97.12
50.640
95.92
33.358
134.64
28.068
NS
10
Ca
9.958
1.306
9.928
1.511
10.818
0.484
10.206
0.579
10.414
0.896
NS
11
IP
9.06
1.593
10.922
1.766
10.054
4.495
8.61
0.993
8.758
1.175
NS
12
TBIL
0.15
0.034
0.15
0.024
0.14
0.171
0.148
0.033
0.17
0.041
NS
13
CREA
0.495
0.020
0.612
0.057
0.548
0.045
0.51
0.064
0.528
0.068
NS
14
BUN
12.86
0.970
17.470
2.587
14.700
3.449
13.004
1.017
14.518
2.302
NS
Urea, alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), triglycerides (TG), total cholesterol (TCHO), total protein (TP), albumin (ALB), total glucose (GLU), calcium (Ca), inorganic phosphorus (IP), total bilirubin (TBIL), creatinine (CREA), and blood urea nitrogen (BUN).
