EGCG Attenuates Uric Acid-Induced Inflammatory and Oxidative Stress Responses by Medicating the NOTCH Pathway

Figure 5

Effects of EGCG on UA-medicated Notch inflammatory signaling pathway. (a) Western blotting analysis of Notch1 was performed to assess the Notch1 transfection in HUVEC. (b) Representative western blot images of proteins of the Notch pathway and inflammatory chemokines detected in whole-cell lysates with antibodies indicated. HUVEC were transfected with Notch1 cDNA with or without EGCG in medium containing UA (mg/dL). (c) Quantitative analysis of intracellular ROS production for the HUVEC with the indicated treatment.