Mitochondrial Respiratory Chain Inhibitors Involved in ROS Production Induced by Acute High Concentrations of Iodide and the Effects of SOD as a Protective Factor

Figure 3

Effect of DETC, SOD, Rotenone, and Antimycin A treatment for 2 h on KI-instigated production of mitochondrial superoxide in FRTL cells. (a) Representative histograms of the mean fluorescence intensity of MitoSOX Red. (b) The production of mitochondrial superoxide instigated by KI in FRTL cells could be increased by DETC, Rotenone, and Antimycin A but decreased by SOD. Dotted line represents the histogram analysis of the blank zero group, the solid line represents the control group or the different treatment groups, respectively. Data were analyzed by mean ± SD. < 0.05 versus control group. < 0.05 versus KI group.

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