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Oxidative Medicine and Cellular Longevity
Volume 2015, Article ID 234952, 15 pages
Review Article

Sleep Deprivation and Oxidative Stress in Animal Models: A Systematic Review

1Unidad de Trastornos del Movimiento y Sueño (TMS), Hospital General Dr. Manuel Gea González/IFC-UNAM, 14080 Ciudad de México, DF, Mexico
2Laboratorio de Neurociencias Moleculares e Integrativas, Escuela de Medicina, División Ciencias de la Salud, Universidad Anáhuac Mayab, 97310 Mérida, YUC, Mexico
3Laboratorio de Pánico y Respiración, Instituto de Psiquiatría, Universidade Federal de Rio de Janeiro (IPUB/UFRJ), 22410-003 Rio de Janeiro, RJ, Brazil
4Instituto de Fisiología, Benemérita Universidad Autónoma de Puebla, 72570 Puebla, PUE, Mexico

Received 16 December 2014; Revised 22 March 2015; Accepted 22 March 2015

Academic Editor: Eugene A. Kiyatkin

Copyright © 2015 Gabriel Villafuerte et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Because the function and mechanisms of sleep are partially clear, here we applied a meta-analysis to address the issue whether sleep function includes antioxidative properties in mice and rats. Given the expansion of the knowledge in the sleep field, it is indeed ambitious to describe all mammals, or other animals, in which sleep shows an antioxidant function. However, in this paper we reviewed the current understanding from basic studies in two species to drive the hypothesis that sleep is a dynamic-resting state with antioxidative properties. We performed a systematic review of articles cited in Medline, Scopus, and Web of Science until March 2015 using the following search terms: Sleep or sleep deprivation and oxidative stress, lipid peroxidation, glutathione, nitric oxide, catalase or superoxide dismutase. We found a total of 266 studies. After inclusion and exclusion criteria, 44 articles were included, which are presented and discussed in this study. The complex relationship between sleep duration and oxidative stress is discussed. Further studies should consider molecular and genetic approaches to determine whether disrupted sleep promotes oxidative stress.