Oxidative Medicine and Cellular Longevity

Review Article

Sleep Deprivation and Oxidative Stress in Animal Models: A Systematic Review

Table 6

Oxidative stress in nonbrain regions during sleep deprivation.
AuthorSleep deprivation protocolMethodAnimal specieDeprivation timeBody regions with oxidative changesGSHGSSGGSH/GSSG ratioGPxCatalaseSODNitritesNOLipid oxidation
Lungato et al. (2013) [59]PSDMSPMale Swiss mice72 hrsSpleenNoNoNoNoYes ↓Yes ↑NoNoYes —
Egydio et al. (2012) [60]PSDMSPMale hairless mice72 hrsSkinNoNoNoNoNoNoNoYes —No
Chang et al. (2008) [61]TSDDOW with EEG monitoringMale Wistar rats5 daysLiverNoNoNoNoNoNoNoNoYes ↑
Chang et al. (2006) [62]TSDDOWMale Wistar rats5 daysNodose ganglionNoNoNoNoNoNoNoYes ↓No
Everson et al. (2005) [63]TSDDOW with EEG monitoringMale Sprague Dawley rats5 or 10 daysLiver
Heart
Lung		Yes ↓
Yes —
Yes —		No
No
No		Yes —
Yes —
Yes —		Yes —
Yes ↑↑
Yes —		Yes ↓↓
Yes —
Yes —		No
No
No		No
No
No		No
No
No		No
No
No
Gopalakrishnan et al. (2004) [53]TSDDOW with EEG monitoringMale Wistar Kyoto rats3–14 daysLiver
Skeletal muscle		No
No		No
No		No
No		No
No		No
No		Yes —
Yes —		No
No		No
No		Yes —
Yes —
de Oliveira et al. (2002) [64]PSDMSPMale Wistar rats96 hrsPlasmaNoNoNoNoNoNoNoNoYes ↓
Catalase: CAT, disc over water: DOW, electroencephalogram: EEG, glutathione: GSH, oxidized glutathione: GSSG, glutathione peroxidase: GPx, grid over water: GOW, hours: hrs, multiple small platforms: MSP, nitric oxide: NO, paradoxical sleep deprivation: PSD, superoxide dismutase: SOD, total sleep deprivation: TSD, ↓: significantly reduced, ↑: significantly increased, —: not significantly increased or decreased, and ↑↑: significantly increased compared with a control and between sleep deprivation times.