Brain-Specific Superoxide Dismutase 2 Deficiency Causes Perinatal Death with Spongiform Encephalopathy in Mice

Figure 2

B-Sod2^−/− exhibited distinct spongiform encephalopathy in the brain. (a–f) Coronal sections of brains from three-week-old B-Sod2^−/−. Motor cortex (a, d), hippocampus (b, e), and brain stem (c, f). A large number of vacuoles were morphologically observed in B-Sod2^−/−. Higher power views (inset) showed neuronal degeneration and malformation with cytoplasmic vacuolization, as well as pleomorphic nuclei (d, e, and f). The scale bars indicate 200 μm.

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